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期刊论文

A Novel Improved Procedure for the Synthesis of Oxazoles

裴坚Wei Huangab* Jian Pei Bingzi Chen Weiwei Pei* and Xiulin Yea

Received in China 21 March 1996; revised 23 April 1996; accepted 24 May 1996, 10131-10136,-0001,():

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摘要/描述

In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed. Copyright

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