Titania was synthesized from laurylamine hydrochloride (LAHC) and Ti(SO4)2 under different acidic conditions. The effect of acidity on the structural and textural evolution of titania has been investigated by X-ray diffraction (XRD), nitrogen adsorption-desorption, transmission electron micrographs (TEM), FTIR spectroscopy and thermogravimetric analysis (TGA). With increasing the pH value in the initial mixture, the obtained samples transformed from nanoparticles with intra-particle mesostructures (pH 0.6 and 2.0) to nanoparticles with nonporous structure (pH 3.7), and finally to worm-like porous materials with inter-particle mesostructures (pH 4.2)resulted from the aggregates of nanoparticles. The obtained mesoporous nanoparticles (pH 0.6 and 2.0) have mean diameter of ca. 25 nm, and the pore size distributions are bimodal with fine intra-particle pores and larger inter-particle pores. The intra-particle mesostructure not only retard the growth of nanocrystallites, but also prevent phase transition of anatase to rutile at high temperature. The BET surface area of the TiO2 calcined at 300 C decreased from 212 to 74 m2/g with pH increasing from 0.6 to 4.2.