In this paper, the interface crack problems of a multilayered anisotropic medium under a state of generalized plane deformation are considered within the framework of anisotropic theory. A general solution procedure is introduced such that it can be uniformly applied to media with transversely isotropic, ortho-tropic, monoclinic, etc. layers. The problem is reduced to the solution of a system of singular integral equations by means of Fourier transform method and the stiffness matrix formulation. A Jacobi polynomial technique is then used to solve the integral equations numerically. The stress intensity factors are provided. The stress intensity factors have been calculated numerically and displayed graphically.