Mining activities have created huge uncovered slopes, large areas of gangue ground and extensive tailings dams. This paper presents the environmental geochemistry of mining activities in Panzhihua region. The selected elements (Ti, V, Mo, Ni, Pb, Cu) show similar distribution patterns of concentration anomaly in topsoil. These concentration anomalies are located in V-Ti-magnetite slope, gangues dam and coal mine. The distinction between anthropogenic contamination and natural background is made available by the use of the enrichment factor in this study area. The anomalies of EF were smaller than that of concentration. The results from EF show that the selected elements anthropogenic pollution (EF>1) in topsoil were located in both the coal mining area and the V-Ti-magnetite mining area. In addition, the pollution sources of selected elements came from V-Ti-magnetite, slag, gangues, coal and other pollutants from mining activities.