A simple, reliable and reproducible method, based on capillary zone e1ectrOphOresis with amperometric detection (CZE-AD), has been developed for simultaneous determination of four active ingredients in Vc Yinqiao tablets including paracetamol, vitamin C, cafeic acid and chlorogenic acid. A carbon-disk electrode was used as working electrode and 0.95V (versus SeE) was selected as detection potentia1. The optimal conditions of CZE experiment were 30 mmol•L-1 borate solution (pH 9.5) as running buffer, 14 kV as separation voltage and 8s (l4kV) as electro-kinetic sampling time. Under the selected optimum conditions, paracetamol, vitamin C, caffeic acid and chlorogenic acid could be perfectly separated within 22min, and their detection limits (S/N=31 ran ged from 5×l0-7 to 1×l0-6mol•L-1. Th is proposed method demonstrated good reproducibility with relative stan dard deviations of less than 3％ for both migration time and peak current (n＝7). The utility of this method was demonstrated by monitoring a kind of compound medicine named Vc Yinqiao tablets and the assay results were sarisfactory.