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期刊论文
Efficient Synthesis of 2-Ethyl-A-ring Analogues of 19-Nor-1α, 25-dihydroxy Vitamin D3
CHEM. RES. CHINESE U. 2003, 19 (2): 165-173,-0001,():
The novel 19-nor-lα, 25-dihydroxy vitamin D3 analogues possessing an ethyl at the 2-position (4 and 5), were synthesized by coupling 25-hydroxy Windaus-Grundmann ketone derivative 20 with A-ring synthons (15 and 19) respectively, The enantioselective synthesis of substituted bicyclic[3,1.0] hexanes structure A-ring synthons, started from all-cis-3, 5-dihydroxy-4-ethyl-1-(methoxycarbonyl) cyclohexane via lipase-catalyzd asymmetrization, was demonstrated.
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