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王晓民
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期刊论文
Triptolide inhibitsTNF-a, IL-1
Lippincott Williams & Wilkins Vol. 14, No. 7, 23 May 2003，-0001，（）：
Microglia are believed to participate in the mediation of neurodegeneration through producing a variety of cytotoxic factors upon activation. Pharmacological intervention inmicroglial activation may therefore exert a neuroprotective effect. In exploring pharmacological agents that can effect microglial activation, we found in this study that triptolide possesses a powerful inhibitory influence over microglia. Pretreatment with triptolide was able to dose-dependently reduce the lipopolysaccharide (LPS)-induced nitrite accumulation and tumor necrosis factor-a and interleukin-1
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