Genotoxic effects on spermatozoa of carbaryl-exposed workers，成果详细信息-中国科技论文在线

王心如

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Genotoxic effects on spermatozoa of carbaryl-exposed workers

王心如， Yankai Xia ， * Senping Cheng ， * Qian Bian ， * Lichun Xu ， * Michael D. Collins ， † Hebron C. Chang ， * Lin Song ， * Jiayin Liu ， ‡ Shoulin Wang ， * and Xinru Wang* ，

ToxSci Advance Access published (2004)1-32，-0001，（）：

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摘要/描述

Carbaryl, one of the most important insecticides,is widely produced and used. To explore carbaryl-induced genotoxic effects of spermatozoa, particularly DNA damage and chromosome aberrations(CA),we firstly examined conventional semen parameters, the progression and motion parameters of the spermatozoa among 16 carbaryl-exposed workers and 30 internal and external control individuals.Sperm DNA damage represented as positive percentage of DNA fragmentation was detected by a modified terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay.Then numerical CA of chromosome X,Y and 18 were investigated by multicolor fluorescence in situ hybridization (FISH). The results showed significant differences in the percentage of sperm abnormality between carbaryl-exposed group and the external control group (P=0.008). Mean (

关键词: carbaryl; sperm; genotoxic effect; DNA fragmentation; TUNEL; chromosome aberration; aneuploidy; FISH ，

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