Immune responses in Balb/c mice induced by a candidate SARS-CoV inacivated vaccine prepared from F69 strain，成果详细信息-中国科技论文在线

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Immune responses in Balb/c mice induced by a candidate SARS-CoV inacivated vaccine prepared from F69 strain

，，，，，，，，，，，，，，，，，，王一飞 Chuan-hai Zhang a b f Jia-hai Lu c ** Yi-fei Wang a Huan-ying Zheng e Sheng Xiong a Mei-ying Zhang a Xin-jian Liu a Jiu-xiang Li a Zhuo-yue Wan e Xin-ge Yan e Shu-Yuan Qi f Zhiyong Cuig Biliang Zhang d g *

C.-h. Zhang et al./Vaccine23(2005)3196-3201，-0001，（）：

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摘要/描述

The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freunds adjuvant, Al(OH)3 adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies.

关键词: SARS coronavirus ( ， SARS-CoV) ，， Inactivated vaccine ， Immunogenicity ， Balb/ ， c m]ouse

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