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期刊论文

Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cellsq

万涛Lili Sui Weiping Zhang Qiuyan Liu Taoyong Chen Nan Li Tao Wan Min Yu and Xuetao Cao*

Biochemical and Biophysical Research Communications 304(2003)393-398,-0001,():

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摘要/描述

Septins are a family of cytoskeletal proteins with GTPase activity involved in various cellular biological processes. Here, we describe the identification of septin 10, a novel septin family member from human dendritic cells. The 3018-bp full-length cDNA potentially encodes a 517-residue peptide, sharing closest homology to human septin 8 and septin 6. With a conserved GTP-binding motif at its N-terminus, septin 10 protein can bind to GTP and exert GTPase activity. Human septin 10 gene is electronically mapped to 8q11.2-12. It is ubiquitously expressed in normal tissues, with the abundant expression in heart and kidney, lacenta, skeletal muscles, liver and lung, as well as various tumor cell lines. Interestingly, dendritic cells express upregulated septin 10 upon LPS-induced maturation. Based on its GFP-fusion protein, septin 10 is found to localize in cytoplasm and nucleus, with a subcellularpatter n independent of the filamentous state of actin.

【免责声明】以下全部内容由[万涛]上传于[2005年05月19日 19时05分16秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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