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期刊论文

Correlation of Lymphocyte Heat Shock Protein 70 Levels with Neurologic Deficits in Elderly Patients with Cerebral Infarction

邬堂春Xingfang Jin MD Chengfeng Xiao PhD Robert M. Tanguay Li Yang Feng Wang Ming Chen Xiaoye Fu Ru Wang Jie Deng Zhijun Deng Yongyong Zheng Qingyi Wei Tangchun Wu

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摘要/描述

PURPOSE: To assess the association between heat shock protein 70 (HSP70) levels and the severity of ischemic stroke in elderly patients. METHODS: We conducted a case-control study to investigate the changes in lymphocyte HSP70 levels by immunoblot in 65 elderly patients with mild (n=22), intermediate (n=21), or severe (n=22) stroke, and in 34 healthy controls. We analyzed correlations between HSP70 levels and neurologic deficit scores on days 1, 15, and 30 after the onset of stroke. RESULTS: Mean ( SD) HSP70 levels were higher in all strokepatients compared with controls (mild stroke: 709 194 units; intermediate: 585

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