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期刊论文
Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique
Journal of Pharmaceutical and Biomedical Analysis 36(2004)169-174，-0001，（）：
A micellar electrokinetic chromatography (MEKC) method was developed for the determination of nateglinide in animal plasma by on-line sweeping technique, in which plasma samples were simply deproteinized with acetonitrile, and analyzed with 16 mmol/L NaH2PO4+6mmol/L Na2B4O7+60mmol/L sodium dodecyl sulfate (SDS) (pH 7.14) as the running buffer, a fused-silica capillary as the separation tube, 21 kV as the running voltage and UV detection at 214nm. Under these conditions, more than 100-fold enrichment of nateglinide was obtained with the good linear relation in the range of nateglinide plasma concentration 0.2-7mg/L (R=0.998). The method could be applied successfully to determine trace drugs in clinical analysis.
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