This paper focuses on the temporal and spatial change of industrial structure in Guangdong Province since the 1990s. The attention is initially paid to the change of industrial structure through analyzing the structure change of the three sectors, and the change of internal structures of agriculture, industry and tertiary sector respectively. Then the spatial differences of industrial restructuring are analyzed based on the four economic regions which have been agreed in the academic field: the Zhujiang (Pearl) River Delta, northern mountain region, east and west wings. Thirdly, the reasons for the spatial differences of industrial restructuring are examined. Finally a short conclusion is drawn and some suggestions for the regional integration are put forward.