In this paper, a non-linear, rigid-elastic coupling multibody system dynamic model is built for a city low-floor bus by using the integration of CAD/CAM/CAE techniques. Finite element analysis models of some flexible components are incorporated to the multi-body vehicle model. The non-linear properties of air spring and dampers are also included. Simulations are carried out in different operation conditions to investigate vehicle ride and handling performances. Based on the comparison of simulation results with field experiment results, the model is validated and the effectiveness of the modeling approach is proved.