Bottomash, as a byproduct of coal fired electric power plants, has recently been used in constructing transportation facilities. However, the use of bottom ash in asphalt mixture is still in early stages. The moisture resistance of asphalt mixtures containing bottom ash was not adequately researched. This study investigated the moisture susceptibility of asphalt mixtures containing bottom ash. Eight asphalt mixtures produced with one type of asphalt cement, two types of aggregate, three sources of bottom ash, and lime additive were evaluated using the principles in AASHTO T283. Analysis on test data indicated that granite mixtures had higher tensile strength (TS) values than limestone mixtures in dry condition. The lime or bottom addition did not substantially change TS values. All mixtures tested met the Superpave volumetric mix design requirement of tensile strength ratio (TSR) after one freeze-thaw cycle. The addition of lime significantly improved the moisture susceptibility of the asphalt mixtures as measured by TSR. With lime addition aggregate type, bottom ash addition, and bottom ash source were all insignificant with respect to TSR. Based on TSR rate (TSRR) values, the addition of lime also significantly improved the moisture susceptibility of the asphalt mixtures subjected to multiple freeze-thaw cycles, while lime addition aggregate type and bottom ash addition were insignificant. However, bottom ash source was a factor statistically significant in relating to TSRR, which was not found for TSR. Without lime addition, bottom ash played a role similar to lime in improving TSRR for the materials tested.