This paper discusses thermal comfort inside residences of three cities in the hot-humid climate of central southern China. Only a few thermal comfort studies have been performed in hot-humid climates and none in Central Southern China. Field sampling took place in the summers of 2003 and 2004 by obtaining 110 responses to a survey questionnaire and measuring environmental comfort variables in three rooms in each of 26 residences. The objectives are to measure and characterize occupant thermal perceptions in residences, compare observed and predicted percent of dissatisfied and discern differences between this study and similar studies performed in different climate zones. Average clothing insulation for seated subjects was 0.54 clo with 0.15 clo of chairs. Only 48.2% of the measured variables are within the ASHRAE Standard 55-1992 summer comfort zone, but approximately 87.3% of the occupants perceived their thermal conditions acceptable, for subjects adapt to prevailing conditions. The operative temperature denoting the thermal environment accepted by 90% of occupants is 22.0–25.91. In the ASHRAE seven-point sensation scale, thermal neutral temperature occurs at 28.61. Preferred temperature, mean temperature requested by respondents, is 22.81. Results of this study can be used to design low energy consumption systems for occupant thermal comfort in central southern China.