Chemical contaminants emitted by dried building material influence the indoor air quality in the long term. Re-circulated ventilation is widely used in the actual ventilation systems and it is one of the important factors affecting the indoor contaminant concentration distribution. The objectives of this paper are to simulate the indoor total volatile organic compounds (TVOCs) distribution emitted from a new floor and the total TVOCs quantity inhaled by an occupant with the different fresh air ratios under a re-circulated ventilation system. Furthermore, contribution ratio of pollution source (CRP) index is utilized to calculate the TVOCs contribution ratio to the inhaled contaminant generated from different locations. Finally, the mean TVOCs emission rate and the residual TVOCs percentage within the building material, average concentration and average ventilation effectiveness at the different locations of the room with respect to time are also investigated. The simulation result and analysis are helpful for designing the indoor healthy occupant environment and improving some features of the re-circulated ventilation system.