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张政朴
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期刊论文
Structure Based Library Approach to Photosynthesis Inhibitors: The Solid Phase Synthesis of Hydro-Uracils and Thiouracils
Chinese Chemical Letters Vol. 9, No.2, pp 139-142 1998，-0001，（）：
A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Prepa-ration of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem II D1 protein inhibitors.
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