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期刊论文
Synthesis and antibacterial activity of dualaction agents of alactam antibiotic with cytotoxic agent mitozolomide or temozolomide
Eur. J. Med. Chem. 2002 37 323-332,-0001,():
Dual-action agents 5a-f and 12a-f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dualaction agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a-f active against the non-β-lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, however, little synergistic effect between the β-lactam and the cytotoxic agent was observed. 12a-f demonstrated some synergistic effect against bacteria. 12a, in particular, is active against ampicillin resistant (β-lactamase-producing) strains of Serratia marcescens. 2002 Published by E ditions scientifiques et marcescens.
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