Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors，成果详细信息-中国科技论文在线

郑从义

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Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

郑从义， Jieqing Zhu ， a ， Gengfu Xiao ， b ， Yanhui Xu ， c ， Fang Yuan ， d Congyi Zheng ， b Yueyong Liu ， a Huimin Yan ， b David K. Cole ， d John I. Bell ， d Zihe Rao ， c Po Tien ， * and George F. Gaoa ， d ， *

Biochemical and Biophysical Research Communications 319(2004)283-288，-0001，（）：

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摘要/描述

Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is a newly identified member of Family Coronaviridae. Coronavirus envelope spike protein S is a class I viral fusion protein which is characterized by the existence of two heptad repeat regions (HR1 and HR2) (forming a complex called fusion core). Here we report that by using in vitro bio-engineering techniques, SARS-CoV HR1 and HR2 bind to each other and form a typical 6-helix bundle. The HR2, either as a synthetic peptide or as a GSTfusion polypeptide, is a potent inhibitor of virus entry. The results do show that SARS-CoV follows the general fusion mechanism of class I viruses and this lays the ground for identification of virus fusion/entry inhibitors for this devastating emerging virus.

关键词: SARS-CoV ， Coronavirus ， Spike( ， S) ， protein ， Fusion core ， Heptad repeat ( ， HR1 and HR2) ，， Inhibition

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