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【期刊论文】Spatial learning and morphine-rewarded place preference negatively correlates in mice
吴春福, Nan-Jie Xu, , Ling-Zhi Wang, Chun-Fu Wub, Gang Pei
N. -J. Xu et al. Pharmacology, Biochemistry and Behavior 68 (2001) 389-394,-0001,():
-1年11月30日
Accumulating evidence has indicated that there might exist some correlation between opiate reward and certain kinds of learning and memory processes. The present study attempted to investigate the correlation between individual differences in morphine reward and capacities in spatial learning and spontaneous alternation. In the present studies, good-response (GR) and poor-response (PR) mice were respectively selected according to their performance in a spatial learning test involving the Morris water maze or in a spontaneous alternation task using the Y-maze. In a place preference conditioning procedure, morphine (3.0 mg/kg) produced significant conditioned place preference (CPP) in both GR and PR mice selected by using either the Morris water maze or the Y-maze. The PR mice selected with the Morris water maze showed significantly more CPP induced by morphine than the GR mice. However, no detectable difference was observed in morphine-induced CPP between the GR and PR mice selected with the Y-maze. These results suggested that the variation in morphine-induced CPP in mice is somehow differentially related to that of spatial learning but unlikely to that of spontaneous alternation.
Morphine, Conditioned place preference, Morris water maze, Y-maze spontaneous alternation task
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吴春福, Mei Huang, Wen Liu, Qiang Li, Chun Fu Wu
M. Huang et al. Brain Research 944 (2002) 90-96,-0001,():
-1年11月30日
Previous studies have shown that acute systemic administration of ethanol induced ascorbic acid release in the striatum. However, the pharmacological implications of ethanol-induced striatal ascorbic acid release are unclear. In the present study, ethanol-induced extracellular changes of ascorbic acid and hydroxyl radical levels were detected in rat striatum by using brain microdialysis coupled to high-performance liquid chromatography with electrochemical detection. It was found that both in male and female rats, ethanol (3.0g/kg, i.p.) increased striatal ascorbic acid release in the first 60 min after ethanol administration. Meanwhile, the extracellular hydroxyl radical levels, detected as 2, 3- and 2, 5-DHBA, were significantly decreased. However, when the ascorbic acid levels returned to the baseline, hydroxyl radical levels rebounded. Administration of DL-fenfluramine (20mg/kg, i.p.) had no effect on the basal levels of ascorbic acid and hydroxyl radical, but significantly blocked ethanol-induced ascorbic acid release and increased hydroxyl radical levels significantly. Exogenous administration of ascorbic acid (20mg/kg, s.c.) increased the extracellular levels of ascorbic acid in the striatum, and inhibited the increase of 2, 3- and 2, 5-DHBA in DL-fenfluramine plus ethanol group. These results provide first evidence that release of endogenous ascorbic acid in the striatum plays an important role in preventing oxidative stress by trapping hydroxyl radical in the central nervous system.
Ethanol, Ascorbic acid, Hydroxyl radical, DL-Fenfluramine, Striatum, Microdialysis (, rat),
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【期刊论文】Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons
吴春福, Jing-Yu Yang, Kazuho Abe, Nan-Jie Xu, Norio Matsuki, Chun-Fu Wu
J. -Y. Yang t al. Neuroscience Letters 328 (2002) 165-169,-0001,():
-1年11月30日
The effect of oleamide on apoptosis was investigated by using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide reduction assay, DNA staining assay with propidiumiodide and caspase-3 activity analyses. The present results showed that oleamide significantly attenuated the cell death and nuclear condensation of cultured rat cerebellar granule neurons induced by K+ deprivation in a dose-dependent manner. The oleamide actions were well parallel with the attenuation of caspase-3 activity in the process of apoptotic death. Moreover, neither elaidic acid nor stearic acid, two fatty acids structurally related to oleamide without the Δ9-cis double bond, had similar effects on the cell death, suggesting the selectively structural features of oleamide required for this action. These data provided the first evidence of a protective effect of oleamide against apoptosis in a structurally specific manner.
Oleamide, Apoptosis, Cerebellar granule neurons, Δ9-cis double bond
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吴春福, Gong Cheng Zuo, Jing Yu Yang, Yue Hao, Ying Xu Dong, Chun Fu Wu
G. C. Zuo et al. Toxicology Letters 169 (2007) 253-258,-0001,():
-1年11月30日
It is controversial regarding to the roles of acetaldehyde and ethanol in the central nervous system. In the present study, the effects of acetaldehyde and ethanol on extracellular levels of glutamate, taurine and GABA in the anterior cingulate cortex (ACC) of freely moving rats were investigated by using the microdialysis technique coupled to high performance liquid chromatography (HPLC) with fluorescent detection. The result showed that glutamate levels were significantly decreased after acute administration of acetaldehyde (AcH, 20 and 100mg/kg, i.p.), while taurine levels were significantly increased after the higher dose of acetaldehyde (100mg/kg, i.p.). GABA levels had no changes at any doses of acetaldehyde tested. Interestingly, similar changes of these amino acids were induced by ethanol (EtOH, 3g/kg, i.p.) when sodium azide (NaN3, 10mg/kg, i.p.), a catalase inhibitor that can reduce brain ethanol metabolism, was used simultaneously. These findings suggest that acetaldehyde and ethanol have the similar effects on the extracellular output of glutamate, taurine and GABA in the ACC.
Acetaldehyde, Ethanol, Glutamate, Taurine, GABA, Anterior cingulate cortex
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吴春福, Yue Hou, , Chun Fu Wu, Jing Yu Yang, Tao Guo
Y. Hou et al. Progress in Neuro-Psychopharmacology & Biological Psychiarty xx (2006) xxx-xxx,-0001,():
-1年11月30日
Many schizophrenic patients exhibit impairments in neurocognitive functions. Typical antipsychotic drugs such as haloperidol, have limited or even detrimental influence on cognitive functions. In contrast, atypical antipsychotic drugs, such as clozapine and olanzapine, may improve memory function in schizophrenics. However, only a few studies have been conducted to directly compare the effects of olanzapine, clozapine and haloperidol on memory functions in animal models. Thus, their effects on this issue were investigated in the present studies by using one-way step-through passive avoidance task and Morris water maze as models of learning and memory. The results showed that olanzapine did not affect acquisition, consolidation or retrieval process in step-through test. Moreover, it improved spatial learning function in mice in Morris water maze task. Clozapine and haloperidol appeared to impair acquisition process and consolidation process, respectively, in step-through test. Both drugs impaired spatial learning function in mice in Morris water maze task. The results suggested a positive implication for the clinical medication of olanzapine in schizophrenic treatment.
Clozapine, Haloperidol, Memory, Morris water maze, Olanzapine, Step-through test
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