目的：应用血清药理学方法检测中药肠安泰及其主要成分的药物血清对 Co26lu大肠癌细胞体外杀伤能力。方法：5组大鼠除 5-Fu血清组按30mg/kg予腹腔注射，给药 2h后腹主动脉采血外，其余4组均 按0.6ml·kg-1·d -1分别给予肠安泰 (干膏)、大黄 (干膏)、藤梨根 (干膏)、生理盐水灌胃，选用2种 不同采血时间。一 日采血：用药 1h后眶静脉采血 2ml；三 日采血：末次用药后 1h腹主动脉采血，无菌分离血清。采用 MTF法观察药物血清对细胞的杀伤作用。结果：肠安泰及其单味药与 5-Fu的不同浓度药物 血清对Co26lu细胞均有不同程度的体外杀伤能力，并呈剂量依赖性。结论：肠安泰能够抑制肿瘤细胞的生长及转移。

We have previously demonstrated that oral administration of bovine lactoferrin (bLF) markedly increases CD4+ and CD8+ T cells and NK (asialoGM1+) cells in the blood of tumor-bearing mice and enhances anti-metastatic activity. In this paper, we document that oral administration of bLF and bLF-hydrolysate (bLFH) is associated with strong increases in CD4+ and CD8+ T, as well as asialoGM1+ cells in lymphoid tissues and lamina propria of the small intestine in mice, especially in tumor-bearing animals in which Co26Lu cells were implanted subcutaneously. Moreover, IgM+ and IgA+ B cells in lamina propria of the small intestine were also significantly increased by bLF and bLFH. Bovine apo-transferrin (bTF) did not exhibit such activity. In the colon, only CD8+ cells were significantly increased by treatment with bLF, while asialoGM1+ cells were significantly decreased. bLF and bLFH induced cytokines to activate T, B and asialoGM1+ cells. Administration of bLF and bLFH, but not bTF, increased production of interleukin-18 (IL-18), interferon-gamma (IFN-γ ) and caspase-1 in the mucosa of the small intestine. Particularly high levels of IL-18 were found in the epithelial cells of the small intestine. Moreover, administration of bLF and bLFH, but not bTF, induced IFN-γ presenting cells in the small intestine. Caspase-1, which processes proIL-18 to mature IL-18, was also induced in the epithelial cells of the small intestine following treatment with bLF and bLFH, but not with bTF. These results suggest that enhanced production of IL-18 and IFN-γ and caspase-1 induction by treatment with bLF may be important for elevation of intestinal mucosal immunity.

目的：探讨从吗啡向芬太尼持续注入转换的适当换算比例。方法：通过20例癌性疼痛患者的回顾性临床调查，对疼痛程度、药物不良反应及治疗满意度进行评价。结果：本组转换后1周内稳定(转换前后疼痛强度无明显变化)(Good组)的有17例，不稳定(Poor组)的有3例。芬太尼注射剂和吗啡有同等的镇痛效果；转换后能够减轻副作用、提高满意度。结论：推荐从低剂量吗啡向芬太尼注射剂转换的换算比例是72：1，并且推测从非低用量吗啡向芬太尼注射剂转换的换算比例小于72：1有可能达到稳定。但不可能确定从吗啡向芬太尼持续注入转换的具体换算比例，应考虑转换前吗啡用量，再行确定转换的具体比例。

指出，中医学是建立在整体、立体思维基础上，以古代哲学思想为指导，以黑箱、试错法为主要研究方法，以宏观整体揭示人体生命活动。从三个方面，即：西医的迅猛发展及难题，中医的稳步发展及其困惑，对立即互补等作了论述。认为，未来的医学要采取系统思维方式，注重运用整体观念研究系统的动态变化。中医必须充分利用现代科学技术手段完善。