AIM：To explore the regularity of multi-meridians controlling a same viscus (MMCSV) METHODS: The rabbit gastric ulcer model was established by ethanol intragastric instillation. Fifty-six rabbits were randomly divided into normal group (NG), model group (MG), model plus acupuncture at Foot Yangming Meridian group (YMG), model plus acupuncture at Foot Taiyin Meridian group (TYG), model plus acupuncture at Foot Shaoyang Meridian group (SYG), model plus acupuncture at Foot Jueyin Meridian group (JYG), model plus acupuncture at Foot Taiyang Meridian group (TYMG), 8 rabbits each group. Gastric mucosal nitric oxide (NO) and nitric oxide synthase (NOS) were assayed by the nitric acid reductase method, and prostaglandin E2 (PGE2) and epidermal growth factor (EGF) were measured by radioimmunoassay. The comprehensive effects were analyzed by weighting method. RESULTS: Compared to MG, SYG, JYG and TYMG, the rabbits gastric mucosal injury index (GMII) reduced very significantly in YMG (P<0.01). And compared to MG, the GMII also reduced significantly in TYG (P<0.05). NO, NOS, PGE2 and EGF increased very significantly in YMG (P<0.01). The EGF in YMG also increased significantly than that in TYG compared to those in MG, SYG, JYG and TYMG（P<0.05）. The PGE2 and EGF also increased very significantly in TYG than those in MG, JYG and TYMG (P<0.01). While compared to SYG, the NOS increased significantly in TYG (P<0.05). NOS was the highest in YMG (P<0.01), and was higher in TYG than in MG (P<0.01). CONCLUSION: MMCSV is common. The Foot Yangming Meridian is most closely related to the stomach, followed by Foot Taiyin Meridian, Foot Shaoyang Meridian and Foot Jueyin Meridian. Foot Taiyang Meridian has no correlation with the stomach.

This study was performed to explore the effect and significance of gastric mucosal histology and ITF mRNA in stress-related rats with lectroacupuncture (EA) on the stomach channel and gallbladder channel. Forty rats were randomly divided into 4 groups: blank control group, model control group, Stomach Meridian of Foot-Yangming(SMFY) group, Gallbladder Meridian of Foot-Shaoyang (GMFY) group. After some procedures, all rats (except normal group) were made model by WRS on day 7. Then the gastric mucosa tissure of each rat was taken off after assessment of gastric mucosal lesion index(GUI), and half of above tissue in each group of was detected the expression of ITF mRNA by Reverse-transcriptase- polymerase chain reaction(RT-PCR) method, meanwhile the gastric mucosal ulcer index（UI） and the histological change and degree of injury of gastric mucosa were observed grossly under light microscope or magnifier. As a result, the UI value in SMFY/ GMFY group decreased obvious or extremly obvious（P﹤ 0.05 or 0.01）; EA had a tendency of improving: The level of ITF mRNA expression of SMFY group was strongly higher than that of model group(P﹤0.01), while that of GMFY group was high than model group but no statistic difference(P﹥0.05); Mucosal hyperaemia and edema but little hemorrhage and gastric ulcer could be observed in group with EA under light microscope, and that of SMFY group was more significant than GMFY. The difference effect of gastric mucosal protection by EA on stomach channel and gallbladder channel, was related to the expression variance of intestinal trefoil factor.

目的：找出针、药及针药结合三者的最佳治疗方法，并为电针手厥阴心包经内关穴 对冠心病心肌缺血具有良好的调整作用提供临床依据。方法通过电针内关穴、口服复方丹参滴丸及针药结合等三种不同治疗方法对冠心病心肌缺血患者心肌耗氧量和临床症状积分的改变进行客观疗效比较。结果：三种不同治疗方法均能降低心肌耗氧量（P＜0.01），缓解心绞痛，减轻临床症状，降低临床症状积分（P＜0.01），提高疗效；结果显示：针药组＞电针组＞药物组。结论：1.单纯运用电针和口复方丹参滴丸治疗冠心病患者均有较好的疗效，但针药结合运用效果更好。2．电针手厥阴心包经内关穴对冠心病心肌缺血具有良好的调整作用。

目的：观察针刺后血清对胃溃疡大鼠胃黏膜细胞c-myc 基因表达的影响。方法：60 只大鼠随机分为5 组，利用链霉蛋白酶消化法分离胃黏膜细胞，分别用表皮生因子受体（EGFR）抑制剂PD153035 和血清孵育胃黏膜细胞，采用逆转录聚合酶链反应法检测胃黏膜细胞c-myc 基因的表达水平。结果:正常血清组大鼠胃黏膜细胞c-myc mRNA 有微弱表达；胃经血清组和对照血清组大鼠胃黏膜细胞c-myc mRNA 呈现较强上增性表达,其中胃经血清组大鼠上增性表达更加明显，两组相比较有显著性差异(P<0.01)；胃经血清+抑制组和对照血清+抑制组大鼠胃黏膜细胞c-myc mRNA 可见少量表达，分别与胃经血清组和对照点血清组两两相比较有显著性差异 (P<0.01)。结论：针刺血清能刺激胃黏膜损伤修复信号转导通路中c-myc 基因的活化，进而诱导细胞增生，并且存在经脉-脏腑的特异性联系。