The protein binding in the kidney was studied in vivo by cationic ferritin microinfusion into rabbit proximal tubules. After ferritin infusion, the protein was located in the small endocytic vesicles, large endocytic vacuoles, dense apical tubules and lysosomes, initially it was in the apical part of the cells, then progressively with time it was transported to the basal part of the cells. In addition, feritin was seen in small tubulo-vesicular structures in the apical cytoplasm. These structures with a diameter of 0.03-0.05a’m were oftcn found around ferritin-loaded vacuoles and occasionally it connected to these vacuoles. Furthermore, small clusters of ferritin particles were found in the basolatcral intercellular spaces, after tubular microinfusion of ferritin 15 min later only small amounts were observed but the number of cluster increased with time after ferritin infusion. The study demonstrates the transcytosis of protein in rabbit proximal tubules, and describes a novel ferritin containing tubulo-vesicular structures.

Skeletal ages were assessed for 4.902 pairs of hand-wrist and knee radiographs of children aged 2-17 years. The FELS method was used to methods have the same conceptual and statistieal basis. The mean absolute differences, within age and sex-specific groups, ranged from 0.34 to 0.87 years. The SD of the differences ranged from 0.31 to 0.68 years and, like the means, tended to increase with age until about 8-11 years. The means and SD were generally larger for the boys than for the girls, except after 14 years. Within age and sex-specific groups, the maximum absolute differences were from 1.45 to 2.99 years. These maximum differences changed irregularly with age but tended to increase until 11 years in the boys and 9 years in the girls. These large absolute differences between the skeletal ages of the hand-wrist and the knee cannot be explained completely by the effects of observer errors. The means of the relative (signed) differences between the skeletal ages of the hand-wrist and the knee were all close to zero, but there was a wide range within age and sex-specific groups. These skeletal ages of the hand-wrist and the knee are not interchangeable. The 95th percentiles of the absolute differences show that, in at leas 5% of children, the choice of the area for skeletal age assessment will markedly influence the evaluation of individuals. They also demonstrate that descriptions of populations based on distributions of skeletal ages from one part of the skeleton may be misleading.

Sibling correlations are reported for Fels skeletal ages from 2,622 mixed longitudinal hand-wrist radiographs of 285 boys and 276 girls. Because the observed correlations were irregular across age, they were smoothed by using kernel regression. The brother-sister correlations were generally lower than those for the other types of sibling pairs, but they were similar to the brother-brother correlations after 11 years. The sister-sister correlations after 12 years. The present data do not provide clear evidence of involvement of the X chromosome in the timing of skeletal maturation, but after 12 years the present data suggest such an involvement.

本文根据西安市及辽宁省开原县2261名女学生及部分青年女农民的调查，得出了西安市女性月经初漂年龄为13.50±1.21岁；开原县为14.40±1.40岁。月经初潮时间有提前趋势，尤以农村为著。通过不同方法的统计分析，发现寿命表的方法优点较多，现状法调查比较准确。此外，本文还与国内、外的资料做了比较，分析了季节分布的特点，探讨了月经初潮的影响因素。