Objective: To summarize and analyze the therapeutic effect of Yiqi Huoxue Huashi Project for patients with membranous nephropathy. Methods: One hundred and seventy MN patients were divided into two groups. Seventynine patients in Chinese herb group were treated with “Yiqi Huoxue Huashi Project” alone. One hundred patients in the control group were treated with integrated Chinese-Western therapy (“Yiqi Huoxue Huashi Project”combining with Immuno-suppressive agents). Results: The total effective rate at 1, 2, 4-year was 90.20%, 91.43% and 92.86%, respectively. The complete remission rate for more than 4 years was 71.43%. “Yiqi Huoxue Huashi Project” reduced urinary protein excretion and increased plasma albumin level, without significant differences compared with control group. The analysis of 128 cases of nephrotic syndrome patients showed that the total effective rate in Chinese herbs group(49 cases) reached 85.71%, without significant difference compared with control group(79 cases) which reached 82.28% . Conclusion: The therapeutic effect of “Yiqi Huoxue Huashi Project” is definite, with low relapse rate and no side effect. Chinese herbs play an important role in the treatment of intractable nephrotic syndrome.

目的：观察和评价蝉花对慢性肾功能衰竭患者的临床治疗效果。方法：将临床收集的126例CRF患者随机分为蝉花治疗组(n=42)、人工虫草组(n=42)和西药对照组(n=42)，用药治疗180天，检测CRF患者的残存肾功能(Scr、BUN、Ccr)、血脂(TG、TCH)、血清白蛋白（ALb）、血色素(Hb)、红细胞比积(Hct)，通过自身对照和组间对照观察和评价蝉花对CRF的临床疗效。结果：蝉花治疗组在治疗后Scr、BUN比治疗前均明显下降(P<0.01)。蝉花治疗组在治疗后ALb、Hb、Hct均明显高于治疗前，其差异十分明显(P<0.01)。蝉花治疗组患者治疗后的TG和TCH较治疗前有所改善(P <0，05)。结论：蝉花能降低血清肌酐、尿素氮水平，提高肌酐清除率，促进蛋白质的合成，纠正负氮平衡的作用；升高CRF患者血浆白蛋白、血红蛋白量和红细胞比积；能改善CRF患者的甘油三酯和降低血清胆固醇水平的作用。

目的 观察甘草酸及复方中药肾十方对慢性马兜铃酸肾病的疗效。方法 26例符合慢性马兜铃酸肾病的患者，给予甘草酸二铵150mg加中药复方汤剂肾十方治疗3个疗程。观察治疗前后尿素氮(BUN)、血肌酐(SCr)、尿酶及24h尿蛋白排泄量，血红蛋白、红细胞压积。结果治疗后患者临床症状有显著改善，总有效率80.76%；BUN、SCr、尿N-乙酰葡萄胺酶(NAG)、＆-微球蛋白(β2-MG)均显著下降(P<0.05)，血红蛋白、红细胞压积较治疗前升高(P<0.05)。结论甘草酸及复方中药肾十方对慢性马兜铃酸肾病有确切的疗效。