目的：为观察中药治疗慢性肾衰竭(CRF)的疗效。方法：采用5/6肾切除大鼠CRF模型，对肾衰大鼠用中药治疗后的肾功能等血液生化指标及残余肾组织病理情况进行了检查。结果：发现中药可降低CRF大鼠的死亡率，降低血Scr和BUN水平，具有明显的延缓CRF进展的作用。在肾组织病理学改变上，中药能延缓肾小球硬化的进展。结论：中药能有效控制慢性肾衰竭的进展。

Objective: To summarize and analyze the therapeutic effect of Yiqi Huoxue Huashi Project for patients with membranous nephropathy. Methods: One hundred and seventy MN patients were divided into two groups. Seventynine patients in Chinese herb group were treated with “Yiqi Huoxue Huashi Project” alone. One hundred patients in the control group were treated with integrated Chinese-Western therapy (“Yiqi Huoxue Huashi Project”combining with Immuno-suppressive agents). Results: The total effective rate at 1, 2, 4-year was 90.20%, 91.43% and 92.86%, respectively. The complete remission rate for more than 4 years was 71.43%. “Yiqi Huoxue Huashi Project” reduced urinary protein excretion and increased plasma albumin level, without significant differences compared with control group. The analysis of 128 cases of nephrotic syndrome patients showed that the total effective rate in Chinese herbs group(49 cases) reached 85.71%, without significant difference compared with control group(79 cases) which reached 82.28% . Conclusion: The therapeutic effect of “Yiqi Huoxue Huashi Project” is definite, with low relapse rate and no side effect. Chinese herbs play an important role in the treatment of intractable nephrotic syndrome.

本文报道以益气健脾方剂治疗阳离子牛血清造成的家兔膜型肾炎模型，与对照组相比，可减少尿蛋白，提高血清白蛋白，降低α2、β球蛋白及胆固醇，肾小球基底膜之病理损害也明显减轻，并对中药的作用机理做了进一步探讨。

目的 观察甘草酸及复方中药肾十方对慢性马兜铃酸肾病的疗效。方法 26例符合慢性马兜铃酸肾病的患者，给予甘草酸二铵150mg加中药复方汤剂肾十方治疗3个疗程。观察治疗前后尿素氮(BUN)、血肌酐(SCr)、尿酶及24h尿蛋白排泄量，血红蛋白、红细胞压积。结果治疗后患者临床症状有显著改善，总有效率80.76%；BUN、SCr、尿N-乙酰葡萄胺酶(NAG)、＆-微球蛋白(β2-MG)均显著下降(P<0.05)，血红蛋白、红细胞压积较治疗前升高(P<0.05)。结论甘草酸及复方中药肾十方对慢性马兜铃酸肾病有确切的疗效。