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吴隆民, WU Longmin, **, GUO Xia, WANG Jun, GUO Qingxiang, , LIU Zhongli and LIU Youcheng
Vol.42 No.2 SCIENCE IN CHINA (Series B),-0001,():
-1年11月30日
Electron transfer reactions take place readily between 2,2,6,6-tetramethylpiperidine oxoammonium ions (1a, 1b) and phenothiazines (2a--2g), giving corresponding nitroxides (3a, 3b) and phenothiazme radical eations (4a--4g). The rate constants for the electron self-exchange reactions between 1 and 3, as well as between 2 and 4, are determined by EPR and IH NMR line-broadening effect in acetonitrile. Fay application of the Marcus theory, the kinetics of the cross-exchange reactions between 1 and 2 is studied.
electron transfer reaction,, phenothiazine,, oxoammonium ion,, Marcus theory.,
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【期刊论文】Oxidative Reactivity of S-Nitrosoglutathione with Hantzsch 1,4-Dihydropyridine
吴隆民, Yu-Zhu Mao, Mei-Zhong Jin, Zhong-Li Liu, and Long-Min Wu*
,-0001,():
-1年11月30日
Nitric oxide (NO) is an endogenous compound of the body involved in a variety of biological processes,1 including immunity-regulating functions, physiological control of blood pressure, and neurotransmission. Authentic NO in vivo has only a 0.1 s half-life.2 Nitrosothiols (RSNO), which are formed in vivo from the reaction of NO with protein or nonprotein thiols, can increase the effective tissue half-life of NO.3 RSNO is commonly referred to as a NO-donor and is found in various biological systems, such as in human plasma, airways, white blood cells, and rat cerebellum.4 Nitrosoglutathione (GSNO) has been shown to be one of the most aboundant RSNOs,4c,5,6 e.g., 0.3μM in bronchial lavage fluid and 0.7μM in brain, and to exhibit depressor action.7
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吴隆民, Jian-Ming Lü†. L. M. Wu†, J. Geimer‡ and D. Beckert
Phys. Chem. Chem. Phys., 2001, 3, 2053-2058,-0001,():
-1年11月30日
Using laser photolysis of basic anaerobic aqueous solutions of a-glycine, L-a-alanine and a-aminoisobutyric acid containing anthraquinone-2,6-disulfonic acid the two spin-polarized (CIDEP) C
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【期刊论文】EPR study of radicals generated from bioactive S-nitrosothiols and related thiols
吴隆民, Jing Jin, Longmin Wu* and Ziyi Zhang
MAGNETIC RESONANCE IN CHEMISTRY Magn. Reson. Chem. 2002; 40:346-352,-0001,():
-1年11月30日
Thermal or photolytic reactions of bioactive S-nitrosothiols and related thiols in the presence of radical generators in deaerated DMSO or aqueous solutions under argon or saturated with nitric oxide (NO) produced nitroxides and an oxyaminyl radical, which were well characterized by EPR spectra. Nitroxides containing a thiyl substituent were obtained. Possible mechanisms are proposed. Bioactive S-nitrosothiols such as S-nitrosoglutathione, S-nitroso-N-acetylpenicillamine and related thiols such as glutathione and N-acetylpenicillamine were used for the investigation. Radical generators utilized as transient radical sources were 2,2'-azobisisobutyronitrile, 2,2'-azobis (2-methylpropionamidine) dihydrochloride, tert-butyl peroxide and benzoyl peroxide.
electron paramagnetic resonance, S-nitrosothiols, thiols, nitroxides, nitric oxide
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吴隆民, Jing Jin, Longmin Wu* and Ziyi Zhang
MAGNETIC RESONANCE IN CHEMISTRY Magn. Reson. Chem. 2002; 40:284-288,-0001,():
-1年11月30日
Photochemical or thermal decomposition of azo-compounds (such as 2,2'-azobisisobutyronitrile, 2,2'-azobis(2-methylpropionamidine) dihydrochloride, dialkyl peroxides (such as tert-butyl peroxide and diacyl peroxides (such as benzoyl peroxide) in anaerobic nitric oxide (NO)-saturated dimethylsulfoxide (DMSO) or aqueous solutions yielded nitroxides. Well-characterized electron paramagnetic resonance spectra of nitroxides revealed that NO was favorable for reacting with carbon-centered and less stereoinhibited transient alkyl radicals, giving kinds of nitrosoalkane, typically nitrosomethane, which act sequentially as C-nitroso compounds to trap transient radicals present in solution, yielding spin-trapping adducts, i.e. nitroxides. Radicals, including sulfinyl radicals from UV-irradiated DMSO, were trapped by the in situ formed CH3NO. O-centered radicals could not add to the freshly formed C-nitroso compounds. Possible mechanisms are suggested.
EPR, nitroxides, nitric oxide, spin trapping
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