已为您找到该学者7条结果 成果回收站
【期刊论文】Critical roles of TRAIL in hepatic cell death and hepatic inflammation
郑世军, Shi-Jun Zheng, Pu Wang, Galit Tsabary, and Youhai H. Chen
J. Clin. Invest. 113: 58-64 (2004),-0001,():
-1年11月30日
The TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis of tumor cells but not most normal cells. Its role in hepatic cell death and hepatic diseases is not clear. In vitro studies suggest that murine hepatocytes are not sensitive to TRAIL-induced apoptosis, indicating that TRAIL may not mediate hepatic cell death. Using two experimental models of hepatitis, we found that hepatic cell death in vivo was dramatically reduced in TRAIL-deficient mice and mice treated with a blocking TRAIL receptor. Although both TRAIL and its death receptor 5 were constitutively expressed in the liver, TRAIL expression by immune cells alone was sufficient to restore the sensitivity of TRAIL-deficient mice to hepatitis. Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation.
-
28浏览
-
0点赞
-
0收藏
-
0分享
-
99下载
-
0
-
引用
【期刊论文】Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL–/– mice
郑世军, Salah-Eddine Lamhamedi-Cherradi, Shi-Jun Zheng, Kimberly A. Maguschak, Jacques Peschon, Youhai H. Chen
Nature immunology Volume 4, No. 3, March 2003,-0001,():
-1年11月30日
TRAIL, the tumor necrosis factor-related apoptosis-inducing ligand, selectively induces apoptosis of tumor cells, but not most normal cells. Its role in normal, nontransformed tissues is not clear. We report here that mice deficient in TRAIL have a severe defect in thymocyte apoptosis-thus, thymic deletion induced by T cell receptor ligation is severely impaired. TRAIL-deficient mice are also hypersensitive to collagen-induced arthritis and streptozotocin-induced diabetes and develop heightened autoimmune responses.Thus,TRAIL mediates thymocyte apoptosis and is important in the induction of autoimmune diseases.
-
0浏览
-
0点赞
-
0收藏
-
0分享
-
66下载
-
0
-
引用