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陈旻湖
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-1年11月30日
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陈旻湖
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-1年11月30日
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陈旻湖, ADRIAN LEE* AND MINHU CHEN
INFECTION AND IMNONRRY, Aug, 1994, P, 3594-3597,-0001,():
-1年11月30日
In previous studies we found that immunizing mice with a somicate of Helicobacter felis and adjuvant cholera toxin (CT; 10 ug) protected the animals against challenge with viable H. felis. The aim of this study was to determine whether a low dose of CT or its nontoxic B subunit (CTB) was effective as an adjuvant in Helicobacter oral vaceines. Significant protection against viable H. felis challenge was achieved in the amimals immunized with H. felis antigen plus the combination fo 0.5ug fo CT and 10ug fo CTB (96%), with H. felis antigen plus 0.5ug of CT (95)%, and with H. felis antigen plus 10 ug of CTB (83%), No protective effect was found in the mice immunized with either H. fells antigen alone or adjuvant CTB and CT alone. Twenty-six percent fo mice immunized with Helicobacter pylori antigen plus CT (10ug) were protected against H. fells challenge, comfimning the value of the model in predicting effects of immunization im humans. The observation that immunity can be induced with a montoxic adjuvant CTB opens the wsy for human studies with H. pylori waceines and is a further step along the road to effective strategies of prevention fo gastroduodenat diseases of major wirld signififcaace.
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陈旻湖, Minbu Chen a, *, Adrian Lee a, Stuart L. Hazell a, pinjin Hu b, and Yiyang Li c
FEMS Microbiology Letters 116(1994)245-250,-0001,():
-1年11月30日
The common mucosal immune system was stimulated by oral immunisation with jack bean urease and the adjuvant cholera toxin. A high level of local antibody and serum antigbody was imduced in mice following hypermmunisation with thes combination No crass-reacting antibody was found against either Helicobaeter pylon or Helicobacter felis, No protection was observed against oral challenge of immunised mice with living H. felis disproving the interesting hypothesis of pallen and Clayton that plant urease might induce a protective immunity against helieobacter infection.
Helicobacter pylori, Vaccination, Urease,, Animal model
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【期刊论文】Helicobacter pylori Vaccine Status and Implications for Drug Therapy fo Ulcer Disease
陈旻湖, Minhu Chen
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-1年11月30日
Helicobacter pylori is now accepted as the aetiological agent in peptic ulcer disease and has been characterised as a grade I carcinogen. The development of an effective vaccine is therefore desirable, although effective therapies for the eradication of the organism are available. The first step towards the developmetn of an anti-H. pylori vaccine was initiated by the demonstrion that a sonicate of H. felis can protect mice against infection with H. felis. Urease has been identified in the mouse model as a protective antigen. Other virulence factors, such as vacuolate cytotoxin and a heat shoek protein of H-Pylori, have been investigated as candidate vaccine components by the development of a new H. pylori mouse model. Vaccine adjuvants. delivery systems and therapeutic vaccination are likely to be the areas of major progress in the future.
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