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黄培强 , Pei-Qiang Huang, * Liang-Xian Liu, Bang-Guo Wei, and Yuan-Ping Ruan
Org. Lett., Vol. 5, No. 11, 2003,-0001,():
-1年11月30日
Selective and potent neurokinin substance P receptor antagonists (+)-L-733, 060 (1) and (+)-CP-99, 994 (2) have been synthesized starting from a new (3S)-piperidinol synthon derived from L-glutamic acid. The methods featured a C-2 regioselective reduction of glutarimide (9), Lewis acid-promoted Si to C-2 phenyl group migration of 10, and stereoselective reduction of acetylated oxime 19 as the key steps.
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黄培强
,-0001,():
-1年11月30日
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黄培强
,-0001,():
-1年11月30日
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黄培强 , Liang-Xian Liu, Yuan-Ping Ruan, Zheng-Qing Guo, and Pei-Qiang Huang*
J. Org. Chem. 2004, 69, 6001-6009,-0001,():
-1年11月30日
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regioand diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols. The versatility of the method is illustrated by the asymmetric syntheses of neurokinin substance P receptor antagonist L-733,061 (ent-1), (-)-deoxocassine (4), and an inhibitor of HIV proteases (5a).
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黄培强 , Jian-Feng Zheng, Li-Ren Jin, and Pei-Qiang Huang*
Org. Lett., Vol. 6, No. 7, 2004,-0001,():
-1年11月30日
Starting from (3R)-5-benzotriazolyl-3-phenylperhydropyrido[2,1-b][1,3]oxazole 9, the enantiodivergent syntheses of both enantiomers of the marine alkaloids haliclorensin 1 and isohaliclorensin 3 have been achieved. Our syntheses feature ring-expansion reactions for the formation of the aza-macrocycle ring system of 3 and sequential ring-expansion reactions (aza-Claisen rearrangement and Zip reaction) for the formation of the aza-macrocycle ring system of 1.
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