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黄培强 , Liang-Xian Liu, Yuan-Ping Ruan, Zheng-Qing Guo, and Pei-Qiang Huang*
J. Org. Chem. 2004, 69, 6001-6009,-0001,():
-1年11月30日
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regioand diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols. The versatility of the method is illustrated by the asymmetric syntheses of neurokinin substance P receptor antagonist L-733,061 (ent-1), (-)-deoxocassine (4), and an inhibitor of HIV proteases (5a).
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黄培强 , Pei-Qiang Huang, * Jun Deng
Synlett 2004, No. 2, 247-250,-0001,():
-1年11月30日
A flexible two-step asymmetric approach to N-protected (R)-5-alkyl tetramates and (R)-5-alkyl tetramic acid derivatives is described. The method is based on the diastereoselective alkylation of (R)-phenylglycinol derived tetramates 7 and 8, which are the first synthetic equivalents to chiral nonracemic tetramate 5-carbanionic synthons A.
asymmetric synthesis,, alkylations,, chiral auxiliaries,, tetramates,, tetramic acids
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