已为您找到该学者12条结果 成果回收站
黄培强 , Pei-Qiang Huang, * Tian-Jun Wu, and Yuan-Ping Ruan
Lett., Vol. 5, No. 23, 2003,-0001,():
-1年11月30日
A flexible asymmetric approach to 5-alkyl tetramic acid derivatives is described, which is based on the use of 9 as the first synthetic equivalent to chiral nonracemic tetramic acid 5-carbanionic synthon 9b. The existence of the carbanion intermediate 9b was proven by trapping with trimethylchlorosilane. Application of the present method to the synthesis of antifungal alkaloid (+)-preussin, as well as protected (3S,4S)-AHPPA 6, is also described.
-
13浏览
-
0点赞
-
0收藏
-
0分享
-
99下载
-
0
-
引用
黄培强 , Liang-Xian Liu, Yuan-Ping Ruan, Zheng-Qing Guo, and Pei-Qiang Huang*
J. Org. Chem. 2004, 69, 6001-6009,-0001,():
-1年11月30日
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regioand diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols. The versatility of the method is illustrated by the asymmetric syntheses of neurokinin substance P receptor antagonist L-733,061 (ent-1), (-)-deoxocassine (4), and an inhibitor of HIV proteases (5a).
-
33浏览
-
0点赞
-
0收藏
-
0分享
-
122下载
-
0
-
引用