中国科技论文在线

上传时间

2005年06月16日

【期刊论文】Synthesis, Biological Evaluation and DNA Binding Properties of Novel Bleomycin Analogues

杨铭， Zhi-Dong Xu， Min Wang， Su-Long Xiao， Chun-Li Liu， and Ming Yang*

Bioorganic & Medicinal Chemistry Letters 13 (2003) 2595-2599，-0001，（）：

-1年11月30日

Aseries of bleomycin analogues was prepared with a facile synthetic method. All the compounds were shown to display significant antitumor activity against HeLa and BGC-823 cell lines in vitro. The binding properties with CT-DNAand cleavage efficiency to pBR322 DNAwere investigated, the results indicate that there is a positive relationship between DNAcleavage efficiency and the binding affinity to DNA, and the antitumor activity of the bleomycin analogues is enhanced as the hydrophobicity of the C-terminus substituent side chain increased.

47浏览
0点赞
0收藏
0分享
121下载
0

引用

上传时间

2005年06月16日

【期刊论文】Novel Bleomycin Analogues: Synthesis, Antitumor Activity, and Interaction with DNA

杨铭， by Zhi-Dong Xu a)b)， Min Wang a)b)， Su-Long Xiao a)， Yan-Juan Zhang a)， and Ming Yang*a)

HEL VETICA CHIMICA ACTA-Vol.87 (2004)，-0001，（）：

-1年11月30日

摘要

The novel analogues 11

43浏览
0点赞
0收藏
0分享
80下载
0

引用

上传时间

2005年06月16日

【期刊论文】Design and Synthesis of Guanidinoglycosides Directed against the TAR RNA of HIV-1

杨铭， by Min Wang a)， Peng-Fei Tu b)， Zhi-Dong Xu a)， Xiao-Lin Yu a)， and Ming Yang*a)

HEL VETICA CHIMICA ACTA-Vol.86 (2003)，-0001，（）：

-1年11月30日

摘要

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of the Tat protein with the transactivation responsive region (TAR) RNA. Tat-TAR RNA Interaction is mediated by a short arginine-rich domain of the protein. Disruption of this interaction could, in theory, create a state of complete viral latency. Here, four novel 6-amino-6-deoxytrehalose guanidinoglycoside derivatives (10 and 13

37浏览
0点赞
0收藏
0分享
107下载
0

引用

上传时间

2004年12月31日

【期刊论文】Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(Ⅱ) complex of 2H-5-hydroxy-1, 2, 5-oxadiazo[3, 4-f]1,10-phenanthroline

杨铭， Zhi-Dong Xu a， He Liu b， Su-Long Xiao a， Ming Yang a， *， Xian-He Bu b

Journal of Inorganic Biochemistry 90(2002)79-84，-0001，（）：

-1年11月30日

摘要

The complex [Mn(L)(NO3)2(H2O2)] (1) (L=2H-5-hydroxy-1, 2, 5-oxadiazo[3, 4-f]1,10-phenanthroline) was synthesized and characterized by elemental analysis, IR and UV. The crystal and molecular structure of 1 was determined by single-crystal X-ray diffraction; crystal data: light yellow, monoclinic, space group P21/n, Z=4, a=7.432(2)

Mn(， Ⅱ)， complex， 2H-5-Hydroxy-1,， 2,， 5-oxadiazo[3,， 4-f]1,， 10-phenanthroline， Crystal structure， Antitumor activity， DNA-binding interaction

36浏览
0点赞
0收藏
0分享
150下载
0

引用

上传时间

2004年12月31日

【期刊论文】Synthesis and Biological Evaluation of DNA Targeting Flexible Side-Chain Substituted β-Carboline Derivatives

杨铭， Sulong Xiao， Wei Lin， Chao Wang and Ming Yang*

Bioorganic & Medicinal Chemistry Letters 11(2001)437-441，-0001，（）：

-1年11月30日

摘要

A series of 3-substituted-β-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating a bility and their antitumor activity were studied, which agreed well with the molecular modeling results.

34浏览
0点赞
0收藏
0分享
104下载
0

引用