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【期刊论文】Taxachitrienes A and B,Two New Bicyclic Taxane Diterpenoids from Taxus chinensis
方唯硕, Wei-Shuo Fang, Qi-Cheng Fang', X iao·Tian Liang, Yang Lu and Qi-Tai Zheng
Tetrahedron V01. 51. No.31, PP 8483-8490, 1995,-0001,():
-1年11月30日
Two Hew bicyclic taxane diterpenoids. taxaehitrienes A(11 and B (21. were isolatedpom the needles of Taxus chinensis. Their structure were elucidated on the basis of spectroscopic data. The crystal structure of 2 was also presented. It is the fist timefor the isolation ofbicych'c diterpenoid which isproposed as the biogeneticprecursorfor taxanes.
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【期刊论文】Synthesis of the 2a-benzoylamido analogue of docetaxel
方唯硕, Wei-Shuo Fang, * Qi-Cheng Fang and Xiao-Tian Liang
Tetrahedron Letters 42(2001)1331-1333,-0001,():
-1年11月30日
—The 2a-benzoylamido analogue of docetaxel 2 was synthesized with a double inversion of the C-2 configuration as the key step, and its cytotoxic activity towards three tumor cell lines was tested. © 2001 Elsevier Science Ltd. All rights reserved.
paclitaxel, docetaxel, 2-benzoylamido analogue of docetaxel, SN2 double inversion.,
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【期刊论文】Synthesis and Cytotoxicity of 2-Amido Docetaxel Analogues
方唯硕, Wei-Shuo Fang, * Ying Liu, Hong-Yan Liu, Shao-Feng Xu, Liang Wang and Qi-Cheng Fang
Bioorganic & Medicinal Chemistry Letters 12(2002)1543-1546,-0001,():
-1年11月30日
—Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and d-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.
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【期刊论文】Synthesis and Biological Activities of High Affinity Taxane Based Fluorescent Probes
方唯硕
,-0001,():
-1年11月30日
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