中国科技论文在线

上传时间

2009年08月17日

【期刊论文】Crystallographic and NMR studies of antiinfective tricyclic guanidine alkaloids from the sponge Monanchora unguifera

华会明， Hui-ming Hua， a， c Jiangnan Peng， a Frank R. Fronczek， d Michelle Kellye， Mark T. Hamanna， b， *

Bioorganic & Medicinal Chemistry 12(2004)6461-6464，-0001，（）：

-1年11月30日

摘要

Three tricyclic guanidine alkaloids, including 1, 8a;8b, 3a-didehydro-8b-hydroxyptilocaulin (1), 1, 8a;8b, 3a-didehydro-8a-hydroxyptilocaulin(2) and mirabilin B (3), were identified from the marine sponge Monanchora unguifera.1, 8a;8b, 3a-Didehydro-8a-hydroxyptilocaulin(2) is a new stereoisomer of 1, the structure of which was elucidated by spectroscopic analysis, comparison of its spectral data with those of 1, and confirmed by X-ray analysis.Compounds 1 and 2 co-crystallized in an unusual perfect order and packed around an approximate inversion center. A mixture of 1 and 2 is active against the malaria parasite Plasmodium falciparum with an IC50 value of 3.8μg/mL while mirabilin B (3) exhibited antifungal activity against Cryptococcus neoformans with an IC50 value of 7.0μg/mL and antiprotozoal activity against Leishmania donovani with an IC50 value of 17μg/mL.

Tricyclic guanidine alkaloids， Monanchora unguifera， Sponge， X-ray crystallography， Antimalarial， Antifungal.，

55浏览
0点赞
0收藏
0分享
134下载
0

引用

上传时间

2009年08月17日

【期刊论文】A New Biflavonoid from Stellera chamaejasme L.

华会明， Bao Min FENG*， Yue Hu PEI， Hui Ming HUA

Chinese Chemical Letters Vol. 15, No.1, pp 61-62, 2004，-0001，（）：

-1年11月30日

摘要

A new biflavonoid, stelleranol, was isolated from the roots of Stellera chamaejasme L..Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra.

Stellera chamaejasme L.，， flavonoids， biflavonoids

38浏览
0点赞
0收藏
0分享
68下载
0

引用

上传时间

2009年08月17日

【期刊论文】A New Pyrroloquinazoline Alkaloid from Linaria vulgaris

华会明， Huiming HUA， * Maosheng CHENG， Xian LI， and Yuehu PEI

Chem. Pharm. Bull. 50 (10) 1393-1394 (2002)，-0001，（）：

-1年11月30日

摘要

A new alkaloid, 1, 2, 3, 9-tetrahydropyrrolo (2, 1-b) quinazolin-1-carboxylic acid (1), together with eight known compounds, 7-hydroxy vasicine (2), benzyl alcohol β-D-(2'-O-b xylopyranosyl)glucopyranoside(3), benzyl alcohol O-β-D-glucopyranoside(4), benzyl alcohol O-β-D-primveroside(5), 3, 5-dimethyl-4-hydroxy benzaldehyde(6), gluco-syringic acid(7), syringin(8), and liriodendrin(9), were isolated from the plants of Linaria vulgaris. Their structures were established by spectroscopic methods.

Linaria vulgaris， Scrophulariaceae， pyrroloquinazoline alkaloid， 1,， 2,， 3,， 9-tetrahydropyrrolo(， 2,， 1-b)， quinazolin-1-car boxylic acid

43浏览
0点赞
0收藏
0分享
39下载
0

引用

上传时间

2009年08月17日

【期刊论文】A New Monoterpene Glucoside from the Leaves of Betula platyphylla Suk.

华会明， Su Juan WANG， Yue Hu PEI*， Hui Ming HUA

Chinese Chemical Letters Vol. 12, No.4, pp. 343-344, 2001，-0001，（）：

-1年11月30日

摘要

A new monoterpene glucoside, (2E, 6Z)-2, 6-dimethyl-8-β-D-glucosyloxy-2, 6-octadienoicacid, was isolated from the leaves of Betula platyphylla Suk. The structure was established by spectroscopic data.

Betula platyphylla Suk， monoterpene glucoside， leaves.，

59浏览
0点赞
0收藏
0分享
30下载
0

引用

上传时间

2009年08月17日

【期刊论文】A New Caffeoylquiniclactone,Neochlorgeniclatone from the Leaves of Betula platyphylla Suk.

华会明， Su Juan WANG， Yue Hu PEI*， Hui Ming HUA

Chinese Chemical Letters Vol. 12, No.6, pp. 509-510, 2001，-0001，（）：

-1年11月30日

摘要

A new caffeoylquiniclactone, named neochlorgeniclatone, was isolated from the leaves of Betula platyphylla Suk.The structure was established by spectroscopic data.

Neochlorgeniclatone， Betula platyphylla Suk， leaves

56浏览
0点赞
0收藏
0分享
30下载
0

引用