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华会明, Hui-ming Hua, a, c Jiangnan Peng, a Frank R. Fronczek, d Michelle Kellye, Mark T. Hamanna, b, *
Bioorganic & Medicinal Chemistry 12(2004)6461-6464,-0001,():
-1年11月30日
Three tricyclic guanidine alkaloids, including 1, 8a;8b, 3a-didehydro-8b-hydroxyptilocaulin (1), 1, 8a;8b, 3a-didehydro-8a-hydroxyptilocaulin(2) and mirabilin B (3), were identified from the marine sponge Monanchora unguifera.1, 8a;8b, 3a-Didehydro-8a-hydroxyptilocaulin(2) is a new stereoisomer of 1, the structure of which was elucidated by spectroscopic analysis, comparison of its spectral data with those of 1, and confirmed by X-ray analysis.Compounds 1 and 2 co-crystallized in an unusual perfect order and packed around an approximate inversion center. A mixture of 1 and 2 is active against the malaria parasite Plasmodium falciparum with an IC50 value of 3.8μg/mL while mirabilin B (3) exhibited antifungal activity against Cryptococcus neoformans with an IC50 value of 7.0μg/mL and antiprotozoal activity against Leishmania donovani with an IC50 value of 17μg/mL.
Tricyclic guanidine alkaloids, Monanchora unguifera, Sponge, X-ray crystallography, Antimalarial, Antifungal.,
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【期刊论文】A New Biflavonoid from Stellera chamaejasme L.
华会明, Bao Min FENG*, Yue Hu PEI, Hui Ming HUA
Chinese Chemical Letters Vol. 15, No.1, pp 61-62, 2004,-0001,():
-1年11月30日
A new biflavonoid, stelleranol, was isolated from the roots of Stellera chamaejasme L..Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra.
Stellera chamaejasme L., , flavonoids, biflavonoids
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【期刊论文】A New Pyrroloquinazoline Alkaloid from Linaria vulgaris
华会明, Huiming HUA, * Maosheng CHENG, Xian LI, and Yuehu PEI
Chem. Pharm. Bull. 50 (10) 1393-1394 (2002),-0001,():
-1年11月30日
A new alkaloid, 1, 2, 3, 9-tetrahydropyrrolo (2, 1-b) quinazolin-1-carboxylic acid (1), together with eight known compounds, 7-hydroxy vasicine (2), benzyl alcohol β-D-(2'-O-b xylopyranosyl)glucopyranoside(3), benzyl alcohol O-β-D-glucopyranoside(4), benzyl alcohol O-β-D-primveroside(5), 3, 5-dimethyl-4-hydroxy benzaldehyde(6), gluco-syringic acid(7), syringin(8), and liriodendrin(9), were isolated from the plants of Linaria vulgaris. Their structures were established by spectroscopic methods.
Linaria vulgaris, Scrophulariaceae, pyrroloquinazoline alkaloid, 1,, 2,, 3,, 9-tetrahydropyrrolo(, 2,, 1-b), quinazolin-1-car boxylic acid
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【期刊论文】A New Monoterpene Glucoside from the Leaves of Betula platyphylla Suk.
华会明, Su Juan WANG, Yue Hu PEI*, Hui Ming HUA
Chinese Chemical Letters Vol. 12, No.4, pp. 343-344, 2001,-0001,():
-1年11月30日
A new monoterpene glucoside, (2E, 6Z)-2, 6-dimethyl-8-β-D-glucosyloxy-2, 6-octadienoicacid, was isolated from the leaves of Betula platyphylla Suk. The structure was established by spectroscopic data.
Betula platyphylla Suk, monoterpene glucoside, leaves.,
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【期刊论文】A New Caffeoylquiniclactone,Neochlorgeniclatone from the Leaves of Betula platyphylla Suk.
华会明, Su Juan WANG, Yue Hu PEI*, Hui Ming HUA
Chinese Chemical Letters Vol. 12, No.6, pp. 509-510, 2001,-0001,():
-1年11月30日
A new caffeoylquiniclactone, named neochlorgeniclatone, was isolated from the leaves of Betula platyphylla Suk.The structure was established by spectroscopic data.
Neochlorgeniclatone, Betula platyphylla Suk, leaves
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