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周天寿, Tianshou Zhou, , * Luonan Chen, † and Kazuyuki Aihara, ‡
,-0001,():
-1年11月30日
We model a synthetic gene regulatory network in a microbial cell, and investigate the effect of noises on cell-cell communication in a well-mixed multicellular system. A biologically plausible model is developed for cellular communication in an indirectly coupled multicellular system.Without extracellular noises, all cells, in spite of interaction among them, behave irregularly due to independent intracellular noises. On the other hand, extracellular noises that are common to all cells can induce collective dynamics and stochastically synchronize the multicellular system by actively enhancing the integrated interchange of signaling molecules.
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【期刊论文】A mechanism of synchronization in interacting multi-cell genetic systems
周天寿, Tianshou Zhou a, ∗, Luonan Chen b, Ruiqi Wang c
Physica D 211(2005)107-127,-0001,():
-1年11月30日
We investigate a general coupled noisy system with time delays, which may be applied to biologically plausible systems for cell-cell communication in a simplified context. The main conclusion is that appropriate noise intensities and coupling strengths are capable of driving the system to be synchronous. We first provide an analytical treatment for the synchronization process, based on the essential phase-locking mechanism, and then derive sufficient conditions which, if satisfied, ensure existence of the synchrony solution. Finally, a multi-cell system with a synthetic gene regulatory network, which contains both intracellular and extracellular noises and time delays, is adopted to demonstrate effects of extracellular noises and couplings on synchronization.
Synchronization, Gene regulatory network, Stochastic differential equation, Global Hopf bifurcation theorem
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【期刊论文】Excitation functions of coupling
周天寿, Tianshou Zhou*, Luonan Chen† and Ruiqi Wang
PHYSICAL REVIEW E 71, 066211 (2005),-0001,():
-1年11月30日
The responses of nonlinear dynamics of two classes to coupling are investigated. It is shown both analytically and numerically that coupling has an excitation ability in a network of the linearly coupled systems. That is, when an uncoupled system is degenerated to a stable steady state from a limit cycle but in the "marginal" state due to the system parameter, an appropriate coupling strength can excite the limit cycle such that the coupled systems exhibit synchronous oscillation; when the uncoupled system is in a stable limit cycle but close to a chaotic attractor, a certain coupling strength can induce the chaotic attractor such that the coupled systems reach chaotic synchronization. Such excitation functions of coupling are different from its traditional role where coupling mainly synchronizes the coupled systems with the original dynamics of the uncoupled system.
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【期刊论文】Synchronization in fractional-order differential systems
周天寿, Tianshou Zhou a, *, Changpin Li b
Physica D 212(2005)111-125,-0001,():
-1年11月30日
An ω-symmetrically coupled system consisting of identical fractional-order differential systems including chaotic and nonchaotic systems is investigated in this paper. Such a coupled system has, in its synchronous state, a mode decomposition by which the linearized equation can be decomposed into motions transverse to and parallel to the synchronous manifold. Furthermore, the decomposition can induce a sufficient condition on synchronization of the overall system, which guarantees, if satisfied, that a group synchronization is achieved. Two typical numerical examples, fractional Brusselators and the fractional Rossler system, are used to verify the theoretical prediction. The theoretical analysis and numerical results show that the lower the order of the fractional system, the longer the time for achieving synchronization at a fixed coupling strength.
Fractional differential equation, Synchronization, Mode decomposition
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