目的 从材料研制和临床应用的不同角度，探索骨诱导性Ca-P陶瓷在节段性负重骨缺损修复应用的可行性，摸索一套切实可行的修复方法。方法 将烧结温度为1250℃的HA/TCP陶瓷，制成直径18mm×30mm，中心直径4mm贯通的管状，在孔壁预成类骨磷灰石，辅与一定网孔结构的TC4网筒固定，修复家犬股骨中段30mm长节段性缺损。经ANSYS做应力分析，优化材料形态、结构设计，制作材料；实验动物应用，评价缺损骨形态恢复、功能重建、骨再生效果。结果 经应力分析，修复家犬股骨所用陶瓷抗压强度9.057MPa，抗弯强度6.289MPa，TC4网筒壁厚0.3mm，力学性能较匹配。实验动物应用，术中形态恢复良好，术后2月功能重建，修复区骨再生形态、结构好；观察发现修复区骨增生明显，体积均大于原骨。结论 应力分析与优化设计具有优良生物学性能的骨诱导性Ca-P陶瓷及辅助固定装置，在节段性负重骨缺损修复中应用，可达到术中良好地恢复形态，术后及早地重建功能，实现骨缺损修复的主要目标，有重要的理论和现实意义。

In order to identify the possibility of hydroxyapatite-sol being used as a drug carrier and absorbent, an in vivo experimental study was performed. Pure hydroxyapatite microcrystals were synthesized by reaction of high purity Ca(OH)2 and H3PO4 solutions while using an ultrasonic homogenizer. Hydroxyapatite-sol was prepared by dispersing hydroxyapatite microcrystals into physiological salt solution. The hydroxyapatite-sol in different concentrations was injected into veins of both 25 Wistar rats and 5 Beagle dogs. The medium lethal dose was determined as 160 mg/kg. By observing the change of O2 and CO2 gas partial pressure, it was considered that the main cause of death by hydroxyapatite-sol injection was due to the blockage of capillaries. When one-sixth amount of the medium lethal dose was injected into the veins of the dogs, the value of phosphorous increased but calcium and magnesium kept stable. LDH, CPK, GOP and GDT values dramatically increased in 30 min after injection, however, one day after injection, the values returned to normal. Repeated experiments by similar methods were continued on same animals for 2 years in two-week intervals, the results in every experiment were almost same, no chronic damage or permanent side effects were discovered in the two years experiment. According to the results above, it was suggested that the hydroxyapatite-sol could be applied as a drug carrier into blood by using a small amount less than one-sixth of the medium lethal dose.

为阐明斜行骨切开术后骨皮质重叠愈合的过程及其生物学基础，对12只成年猕猴施行双侧下颌支斜行切开术，术后3、6、12周和24周取标本进行下颌支横断面磨片观察和组织学观察，并对2只动物实施术后立即微血管造影检查。结果显示：术后下颌支近心骨段仍有较好的血管充盈，骨段下端无局灶坏死。骨皮质重叠愈合的主要方式为包绕骨断端的大量外骨痂形成，骨皮质重叠区内的骨痂形成较周围慢，至术后24周骨切开部位的内外侧厚度达正常下颌支的2～3倍。结论：下颌支斜行切开术后近中骨段未出现严重的血供下降，通过大量外骨痂的形成，骨皮质重叠可以获得良好的愈合。