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【期刊论文】Characterization of antioxidants present in hawthorn fruits
张泽生, Zesheng Zhang a, Qi Chang b, Min Zhu b, Yu Huang c, Walter K.K. Ho a, Zhen-Yu Chen a, *
Zhang et al./Journal of Nutritional Biochemistry 12(2001)144-152,-0001,():
-1年11月30日
Hawthorn fruit extract has been shown to have many health benefits including being cardiovascular protective, hypotensive and hypocholesterolemic. The present study was carried out to characterize further the antioxidants of hawthorn fruit and their effect on the oxidation of human low density lipoprotein (LDL) and α-tocopherol. The dry hawthorn fruit was extracted successively with ether, ethyl acetate, butanol and water. The ethyl acetate fraction was only effective in inhibition of Cu+2-mediated LDL oxidation. The column chromatographic separation led to isolation of eight pure compounds; namely, ursolic acid, hyperoside, isoquercitrin, epicatechin, chlorogenic acid, quercetin, rutin and protocatechuic acid. All of these phenolic compounds, except ursolic acid, were protective to human LDL from Cu+2-mediated LDL oxidation. They were also effective in preventing the peroxy free radical-induced oxidation of α-tocopherol in human LDL. The inhibitory effect of these compounds on oxidation of LDL and α-tocopherol was dose-dependent at concentrations ranging from 5 to 40µM. In addition, supplementation of 2% hawthorn fruit powder significantly elevated serum α-tocopherol by 18-20% in rats fed a 30% polyunsaturated canola oil diet, as compared with the control. The present results suggest that part of the mechanism for cardiovascular protective effects of hawthorn fruit might also involve the direct protection to human LDL from oxidation or indirect protection via maintaining the concentration of α-tocopherol in human LDL.
Flavonoid, Hawthorn fruit, Low density lipoprotein, α-Tocopherol
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【期刊论文】Antioxidative Activity of Green Tea Catechin Extract Compared with That of Rosemary Extract
张泽生, Zhen-Yu Chen a, *, Li-Ya Wang a, Ping Tim Chan a, Zesheng Zhang a, Hau Yin Chung a, and Chao Liang b
JAOCS 75 9(1998)1141-1145 ,-0001,():
-1年11月30日
This study compared the antioxidative activity of green tea catechin (GTC) extract with that of rosemary extract in canola oil, pork lard, and chicken fat. The GTC extract was obtained from jasmine and longjing green teas and mainly consisted of four epicatechin isomers including (−)epigallocatechin gallate (EGCG), (−)epigallocatechin (EGC), (−)epicatechin (EC), and (−)epicatechin gallate (ECG). The oxidation was conducted at 100±2℃ by monitoring oxygen uptake. The oxygen consumption test demonstrated that GTC extract was much more effective than the rosemary extract against lipid oxidation in canola oil, pork lard, and chicken fat under the conditions of the present study. Together with our previous study which showed that GTC extract was more protective than butylated hydroxytoluene as an antioxidant, these results suggest that GTC as a mixture of EGCG, EGC, EC, and ECG may serve as an antioxidant in processed foods.
Canola oil, chicken fat, epicatechin, green tea, jasmine tea, longjing, pork lard, rosemary.,
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