目的 探讨白藜芦醇对大鼠重症急性胰腺炎炎症介质的作用。方法 应用逆行胰胆管穿刺注射牛黄胆酸钠制 备重症急性胰腺炎大鼠模型。90只大鼠随机分为假手术组、重症急性胰腺炎模型组（sAP）、白藜芦醇治疗组Ⅰ（RESl，5mg/kg）、白藜芦醇治疗组II(REs2，10mg/kg)、白藜芦醇治疗组Ⅲ（REs3，20mg/kg）等5组，每组18只。术后3、6、12h各剖杀6只，观察重症急性胰腺炎大鼠模型腹水的性质、量，测定血清肿瘤坏死因子、白细胞介素6的水平，观察治疗组和模型组生存率的变化。结果 白藜芦醇治疗组与重症急性胰腺炎模型组相比，血清中肿瘤坏死因子、白细胞介素6的水平明显下降，死亡率降低，腹水量减少（P<0.05）。结论 白藜芦醇降低重症急性胰腺炎大鼠死亡率，减少腹水量可能与抑制血清肿瘤坏死因子及白细胞介素6的水平有关。

Objective. To investigate the effects of combined administration of octreotide and methylglucamine diatrizoate in the older persons with adhesive small bowel obstruction. Patients and methods. One hundred and sixty-two consecutive patients who had suffered from adhesive intestinal obstruction without clinical evidence of strangulation or gangrene were randomised into two groups, a control group (treated conservatively, n=82) and a contrast group (treated with combined administration of octreotide and methylglucamine diatrizoate, n=80). A laparotomy was performed in both the two groups if symptoms of strangulation developed or the obstruction did not resolve spontaneously after 72 h. Results. Statistically significant rapid reduction in pain score, lower amount of nasogastric drainage, shorter hospital stay, lower operative rate and lower postoperative morbidity were observed in the contrast group. Among the non-operative patients, earlier passage of stool and gas, earlier first oral intake and shorter duration of nasogastric tube placement were significantly more frequently observed in the contrast group. No difference in the rate of readmission was found between the two groups. Conclusions. Combined administration of octreotide and methylglucamine diatrizoate accelerates resolution of small bowel obstruction by a specific therapeutic effect and is safe for the older persons.

目的 探讨端粒酶逆转录酶（hTERT）和P53基因与甲状腺癌的发生、发展及预后的关系以及它们的相互关系。方法 应用免疫组织化学sP法检测60例甲状腺癌、10例正常甲状腺组织、10例结节性甲状腺肿及10例甲状腺腺瘤组织中hTERT和P53的表达。结果 hTERT和P53阳性率在甲状腺癌中增高（P<0.05）；hTERT与P53日性率在未分化癌、有淋巴结转移或Ⅲ、Ⅳ期病例中增高（P<0.05）：hTERT表达与P53表达具有相关性（P<0.05）。结论 hTERTgn P53的过度表达在甲状腺癌的发生发展过程中具有重要作用，P53突变在转录水平上调控hTERT基因的表达，激活端粒酶可能是甲状腺癌发生发展的重要阶段；hTERT和P53在甲状腺癌中表达的变化可用于评估其生物学行为和判断预后。