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2009年06月10日

【期刊论文】Ethylene diamine tetraacetic acid induced colonic crypt cell hyperproliferation in rats

马清涌， Qing-Yong Ma， Kate E Williamson， Brian J Rowlands

World J Gastroenterol 2004; 10 (2): 218-222，-0001，（）：

-1年11月30日

摘要

AIM: To investigate the effect of ethylene diamine tetraacetic acid (EDTA) on proliferation of rat colonic cells. METHODS: EDTA was administered into Wistar rats, carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in rats was studied with immunohistochemistry. RESULTS: Marked regional differences in cell proliferation were found in all groups. In EDTA-treated animals, total labelling indexes in both proximal (10.00