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2010年07月01日

【期刊论文】Hydrolysis of Dipeptide Heptyl Esters with Newlase F

陈忠周， Zhong Zhou CHEN， Yan Mei LI*， Xiu Fen KOU， Xue LI， Fu Rong HUANG， Hai Yan WANG， Ming Ming MA， Yu Fen ZHAO

Chinese Chemical Letters Vol.12, No.8, pp 693-696, 2001，-0001，（）：

-1年11月30日

Newlase F is a rude enzyme which contains triacylglycerol lipase and acid protease. Hydrolysis of dipeptide heptyl esters with Newlase F was studied in phosphate buffer-organic solvent by HPLC. When the Newlase F's level reached 5 mg/mL under mild condition (pH 7.0, 30℃), the lipase had the highest activity. The reaction was also affected greatly by organic solvents and their concentrations. It is found that protease in Newlase F does not hydrolyze amide bond under this condition (pH 7.0, r.t.).

Newlase F， dipeptide heptyl esters， HPLC.，

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2010年07月01日

【期刊论文】磷酰化氨基酸反应性质的理论研究

陈忠周，杜进堂，李艳梅，谭波，江洋，钟儒刚，赵玉芬

高等学校化学学报，2005，26，540～545，-0001，（）：

-1年11月30日

摘要

采用量子化学计算研究了磷酰化氨基酸的反应性质, 包括N-磷酰氨基酸成肽反应、成酯反应、磷上酯交换反应和磷上的N→O 迁移反应的机理以及计算模型和计算方法的选择, 并从理论上解释了自然界选择α-氨基酸而不是β, γ-氨基酸的实验事实.

N-磷酰氨基酸，五配位磷中间体，量子化学计算，从头算，密度泛函

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2010年07月01日

【期刊论文】催化剂对煤着火特性影响规律的计算机辅助研究(Ⅰ)碱金属、碱土金属盐对煤的催化着火规律①

陈忠周，武增华，许玲，胡鑫尧

计算机与应用化学，1996，13（4）：270～273，-0001，（）：

-1年11月30日

摘要

应用计算机高速采集煤在燃烧过程中的各瞬时温度，通过特殊软件的数据处理，可以直接得到表征煤着火特性的着火温度，并应用该种计算机辅助研究方法，研究碱金属、碱土金属盐类对煤的催化着火影响。研究表明：碱金属、碱土金属盐的催化活性，随对应的金属的第一电离能的减弱而递增。但带结晶水的碱土金属盐例外，其催化活性，明显优于该属不带结晶水的的盐。

煤，催化剂，着火特性，着火温度(，着火点、燃点)，

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2010年07月01日

【期刊论文】Theoretical Study on the Activity of a-COOH and b-COOH of N-Phosphoryl Aspartic Acids

陈忠周， Zhong Zhou CHEN， Bo TAN， Yan Mei LI*， Yu Fen ZHAO

Chinese Chemical Letters Vol.12, No.12, pp 1093-1096, 2001，-0001，（）：

-1年11月30日

摘要

The bio-mimic reactions of N-phosphoryl amino acids are very important in the study of many biochemical processes. The difference of reactivity between a-COOH and b-COOH in phosphoryl aspartic acid was studied by theoretical study (Hartree-Fock and Density Functional methods) in this paper. The intermediates II containing five-membered ring were more stable than III with six-membered ring. While for intermediates III, the isomers with six-membered ring in apical-equatorial spanning arrangement were more stable than those with di-equatorial spanning arrangement. At B3LYP/6-31G** level, it was shown that transition states IV and V involving a-COOH or b-COOH group had energy barriers of DE=58.67kJ×mol-1 and 103.94 kJ×mol-1, respectively. These results were in agreement with the experimental data. So the a-COOH group was involved in form of the intramolecular penta-coordinate phosphoric-carboxylic mixed anhydride intermediates, but not b-COOH group.

α-Carboxylic group， β-carboxylic group， theoretical study， N-phosphorylation

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2010年07月01日

【期刊论文】The Self-catalytic Esterification Reaction of O-Phosphoryl Serine Derivative

陈忠周， Jin Tang DU， Yan Mei LI∗， Zhong Zhou CHEN， Shi Zhong LUO， Yu Fen ZHAO

Chinese Chemical Letters Vol.16, No.7, pp 856-858, 2005，-0001，（）：

-1年11月30日

摘要

O-Phosphoryl serine derivative can perform self-catalytic esterification reaction in the mixture of CH3OH and CHCl3 at the room temperature. The phosphoryl group participation was the key step of the esterification. This type of reactions were proposed through an intermediate of mixed phosphoric-carboxylic anhydride that might provide a clue to the function of the phosphoryl group in the phosphorylated enzymes and in the prebiotic synthesis of protein.

O-Phosphoryl serine， self esterification， phosphoryl group participation.，

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