The biomolecular binding behavior of anticancer drug dacarbazine (DTIC) in the presence of titanium dioxide (TiO2) nanoparticle interface has been studied by using electrochemical methods. The results indicate that the presence of TiO2 nanoparticles can obviously increase the binding affinity of DTIC to DNA or DNA bases and significantly enhance the detection sensitivity for the relative biomolecular recognition.

A non-dense long-chain tethered bipyridinium monolayer linked to an electrode support is reversibly retracted and attracted from and to the electrode respectively by the applied potential. The "molecular machinery" functions of the monolayer are probed by chronoamperometry and contact angle measurements.

The interaction between fl-cyclodextrin (β-CD) and riboflavin together with its electrogenerated intermediate anion radicals has been specifically investigated by in situ electrochemical UV-visible spectroscopy. It appears that the anion radicals are included more tightly than the parents and stabilized in the special microenvironment of the β-CD cavity. The utility of β-CD for probing the existence of an unstable intermediate species at the electrode is also demonstrated.

The effect of fl-cyclodextrin (fl-CD) on the spectral properties of quinine molecules has been specifically studied by absorption/fluorescence and Fourier transform infrared (FTIR) spectroscopy. In particular, FTIR studies of the complexation of aqueous quinine hydrochloride with fl-CD provide fresh insight into the molecular structure of the complex and reveal some important information in relation to the molecular interactions of the cyclodextrin complex system. Nuclear magnetic resonance data support the inclusion conformation of the interaction sites and the presence of hydrogen bonds which stabilize the complexes.

In situ electrochemical static contact angle measurements are employed to probe photoinduced electron transfer processes at electrode surfaces. Photosystems consisting of tris(2,20-bipyridyl)ruthenium(II), (Ru(bpy)32+), N,N0-dimethyl-4,40-bipyridinium (MV2+), Na2EDTA or CdS nanoparticles, MV2+, triethanolamine (TEOA) were included in aqueous droplets that were coupled with a ferrocene monolayer-functionalized electrode. Upon the oxidation of the interface (0.5 V vs. Ag quasi-reference electrode), and the illumination of the systems, photoinduced electron transfer to the modified electrode proceeds. The electron transfer processes yield photocurrents, and the photoelectrochemical transformations are followed by contact angle measurements. Similarly, a CdS/bipyridinium monolayer is assembled on an Au electrode support. The redox transformations of the bipyridinium units control the hydrophilic/hydrophobic properties of the interface, and are followed by contact angle analyses. Irradiation of the CdS/bipyridinium layer associated with the electrode biased at -0.3 V yields a photocurrent. The changes in the wetting properties of the irradiated interface are investigated by contact angle measurements.