In this paper, Particle Swarm Optimization (PSO) algorithm, a new promising evolutionary algorithm, is proposed to train Radial Basis Function (RBF) network related to automatic configuration of network architecture. Classification tasks on data sets: Iris, Wine, Newthyroid, and Glass are conducted to measure the performance of neural networks. Compared with a standard RBF training algorithm in Matlab neural network toolbox, PSO achieves more rational architecture for RBF networks. The resulting networks hence obtain strong generalization abilities.