There are 3 crises in the development of mathematics from its internal, and particularly, the 3th crisis extensively made it to be consistency in logic, which finally led to its more and more abstract, but getting away the reality of things. It should be noted that the original intention of mathematics is servicing other sciences to hold on the reality of things but today’s mathematics is no longer adequate for the needs of other sciences such as those of theoretical physics, complex system and network, cytology, biology and economy developments change rapidly as the time enters the 21st century. Whence, a new crisis appears in front of mathematicians, i.e., how to keep up mathematics with the developments of other sciences? I call it the 4th crisis of mathematics from the external, i.e., the original intention of mathematics because it is the main topic of human beings.

A complex system S consists of m components, maybe inconsistence with m ≥ 2 such as those of self-adaptive systems, particularly the biological systems and usually, a system with contradictions, i.e., there are no a classical mathematical subfield applicable. Then, how can we hold its global and local behaviors or true face? All of us know that there always exists universal connections between things in the world, i.e., a topological graph −→G underlying parts in S. We can thereby establish mathematics over a graph family −→G1,−→G2, · · · for characterizing the dynamic behaviors of system S on the time t, i.e., complex flows. Formally, a complex flow −→G L is a topological graph −→G associated with a mapping L : (v, u) → L(v, u), 2 end-operators A+ vu : L(v, u) → LA + vu(v, u) and A+ uv : L(u, v) → LA + uv (u, v) on a Banach space B over a field F with L(v, u) = −L(u, v) and A+ vu(−L(v, u)) = −LA + vu(v, u) for ∀(v, u) ∈ E −→G holding with continuity equations dxv dt = u∈NG(v) LA + vu (v, u) , ∀v ∈ V −→G, where xv is a variable on vertex v for ∀v ∈ E −→G. Particularly, if dxv/dt = 0 for ∀v ∈ V −→G, such a complex flow −→G L is nothing else but an action flow or conservation flow. The main purpose of this lecture is to clarify the complex system with that of contradictory system and its importance to the reality of a thing T by extending Banach or Hilbert spaces to Banach or Hilbert continuity flow spaces over topological graphs −→G1,−→G2, · · · and establishing the global differential theory on complex flows, characterize the global dynamic behaviors of complex systems, particularly, complex networks independent on graphs, for instance the synchronization of complex systems by applying global differential on the complex flows −→G L .

Actually, different views result in different models on things in the universe. We usually view a microcosmic object to be a geometrical point and get into the macrocosmic for finding the truth locally which results in a topological skeleton or a complex network. Thus, all the known is local by ourselves but we always apply a local knowledge on the global. Whether a local knowledge can applies to things without boundary? The answer is negative because we can not get the global conclusion only by a local knowledge in logic. Such a fact also implies that our knowledge on a thing maybe only true locally. Could we hold on the reality of all things in the universe globally? The answer is uncertain for the limitation or local understanding of humans on things in the universe, which naturally causes the science’s dilemma: it gives the knowledge on things in the universe but locally or partially. Then, how can we globally hold on the reality of things in the universe? And what is the right way for applying scientific conclusions, i.e., technology? Clearly, different answers on these questions lead to different sciences with applications, maybe improper to the universe. However, if we all conform to a criterion, i.e., the coexistence of human beings with that of the nature, we will consciously review science with that of applications and get a right orientation on science’s development.