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罗湘杭, Er-yuan Liao, Xiang-hang Luo, * Xiao-ge Deng, Xian-ping Wu, Hui-juan Liao, Ping-fang Wang, Ji-ping Mao, Xu-ping Zhu, Gan Huang, and Qi-you Wei
ENDOCRINE RESEARCH Vol. 29, No.2, pp. 217-226, 2003,-0001,():
-1年11月30日
Recently our studies have shown that nylestriol in combination with levonorgestrel prevented bone loss, decreased bone turnover rate and increased the maximal loading of bone without obvious side effects in retinoic acid (RA) induced osteoporotic rats. In addition to the animal experiments, we evaluate the effect of Compound Nylestriol Tablet (CNT) on bone mineral density (BMD) in women with postmenopausal osteoporosis. Compound Nylestriol Tablet, which contains 0.5mg of nylestriol (cyclopentylethinyl estriol) and 0.15mg of levonorgestrel per tablet, was authorized as a new anti-osteoporotic agent for clinical trial in postmenopausal osteoporosis. Methods. One year's clinical observation was performed in 191 eligible patients who were randomly divided into two groups (A and B). In group A, 119 patients were treated for one year with CNT (one tablet per week) and in group B, 72 patients with placebo. Bone mineral density of lumbar antero-posterior spine (L1-L4), lateral spine, total hip and total forearm positions including radius
Estrogen replacement therapy, Nylestriol, Levonorgestrel, Bone mineral density.,
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