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2005年03月08日

【期刊论文】Syntheses of Two Cytotoxic Sinapyl Alcohol Derivatives and Isolation of Four New Related Compounds from Ligularia nelumbifolia

赵昱， Yu Zhao， *， †， ‡ Xiaojiang Hao， ‡ Wei Lu， § Junchao Cai， § Hong Yu， ┴ Thierry Sevénet， || and Francüoise Guéritte||

J. Nat. Prod. 2002, 65, 902-908，-0001，（）：

-1年11月30日

摘要

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.

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2005年03月08日

【期刊论文】Lignans from Torreya jackii identified by stopped-flow high-performance liquid chromatography-nuclear magnetic resonance spectroscopy

赵昱， Yu Zhao a， Aslieh Nookandeh a， Bernd Schneider b， Xianfeng Sun a， Bettina Schmitt b， Joachim St

Journal of Chromatography A, 837(1999)83-91，-0001，（）：

-1年11月30日

摘要

Coupled reversed-phase HPLC-NMR spectroscopy has been applied to the rapid detection and identification of plant metabolites of Torreya jackii, a species of Taxaceae. Analysis consisted of gradient HPLC elution and directly coupled H NMR (500 MHz) spectroscopic detection in a stopped-flow mode. Seven lignans were detected and their structures were 1 elucidated, based on their HPLC-1 H NMR spectra and MS data. The structures were confirmed by isolation of the single components followed by conventional NMR measurements.

Torreya jackii， Nuclear magnetic resonance spectroscopy， Lignans

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2005年03月08日

【期刊论文】Eudesmane derivatives from Laggera pterodonta

赵昱， Yecheng Xiao a， c， Qunxiong Zheng a， b， Qijun Zhanga， Handong Sunc， Fran

Fitoterapia 74(2003)459-463，-0001，（）：

-1年11月30日

摘要

A new eudesmane derivative, 4a,5a-dihydroxyeudesma-11(13)-en-12-oic acid, was isolated from Laggera pterodonta.Its structure was elucidated as (1) on the basis of spectroscopic evidence.Mor eover, six known compounds were isolated: pterodontriol A (2), pterodontriol B, pterodonta acid (3), ilicic acid (4), costic acid and b-amyrin.Cytotoxic activity of compounds 2, 3 and 4 was investigated.

Laggera pterodonta， 4a,， 5a-Dihydroxyeudesma-11(， 13)， -en-12-oic acid， Cytotoxic activity

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浙江大学，浙江

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