TiN and Ti-O/TiN films have been deposited on Ti-6Al-4V substrate using plasma immersion ion implantation and deposition (PIII&D). It has been proved that TiN and Ti-O/TiN films both enhance the corrosion resistance of substrate materials. Potentiodynamic polarization curves show that both Ti-6Al-4V substrates deposited with these two kinds of films have lower dissolution urrents than that of the uncoated one. Electrochemical impedance spectroscopy (EIS) measurements indicates that TiN films with high corrosion resistance is mainly due to its barrier-type dense film layer, and that Ti-O/TiN film provides high corrosion resistance is mainly owing to its high corrosion potential (Ecorr). Friction coefficient curves obtained from pin-on-disk wear tests, as well as following SEM observation of wear residual trace width and morphology, indicate that TiN and Ti-O/TiN films both present high wear resistance in comparison with uncoated Ti-6Al-4V.

Over the past decade, much attention has been paid to anti-thrombotic materials applied in artificial organs. Surface modification has shown potential to improve the anti-coagulation of blood-contacting biomedical devices and materials w1-3x. Our in vitro study of Ti-O thin films has recently shown that Ti-O thin films possess superior blood compatibility to low temperature isotropic pyrolytic carbon (LTI-carbon), w1x. In this work, we have focussed our attention onto the in vivo evaluation of Ti-O thin films fabricated by plasma immersion ion implantation (PIII). The samples of titanium coated by Ti-O thin films were implanted in dogs'hearts for 1 month. The results of the implantation showed that no thrombus was found on the surfaces of the Ti-O thin film, although the coagulation occurred on the surfaces of LTI-carbon.

Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving hemocompatibility with Ti-O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti-O films have excellent hemocompatibility. It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved hemocompatibility.

Plasma immersion ion implantation and deposition (PIIID) provides a novel approach to fabricate high quality films by means of utilizing particle filtrated metal plasma and varying acceleration pulse voltages. In this work, investigation on plastic deformation of TiN films synthesized by PIIID was performed by pulling the TiN film-coated stainless steel sheet samples. The surface morphology during the pulling was observed in situ by scanning electron microscopy. No elaminating, peeling or cracking werefound on the coating surfaces. The structure of the films was identified by transmission electron microscopy and atom force microscopy. It is considered that the excellent deformation behavior of the TiN film was related with the nanocrystal structure of the films and the broader filmymatrix interface achieved by the PIII process.

Titanium oxide films were synthesizedon titianium, cobalt alloy and low-temperature istropic pryolytic carbn by ion beam enhanced deposition. The non-stoichiometrical titanium oxide films were obtained. Blood compatibility of the films were evaluated by clotting time measurement, platelet adhesion in vestigation and hemlysis analyses. The results revealed that blood compatibility of the materials was improved by the coating of titanium oxide films. Semiconductor natute fo non-stoichiometric titanium oxide films might be responsible ofor the improvement of blood compatibility.