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梁宏, HUANG Jin, YUAN Yuzhou & LIANG Hong
SCIENCE IN CHINA (Series B) April 2002 Vol. 45 No.2 200~207,-0001,():
-1年11月30日
The binding equilibrium between phosphotungstic acid (H7[P(W2OT)6]
serum albumin,, phosphotungstic acid,, UV spectrum,, fluorescence spectrum,, equilibrium dialysis.,
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梁宏, Hong Liang a, *, Jin Huang a, Chu-Qiao Tu a, Min Zhang a, Yong-Qia Zhou b, Pan-Wen Shen b
Journal of Inorganic Biochemistry 85 (2001) 167-171,-0001,():
-1年11月30日
A notable hysteretic effect has been observed in the interaction of Co(Ⅱ) with human serum albumin (HSA) or bovine serum albumin (BSA) using UV-Visible spectrometry at physiological pH (7.43), which shows that the binding between Co(Ⅱ) and HSA or BSA may induce a slow transition of HSA or BSA from the conformation of weaker affinity for Co(Ⅱ) to one of stronger affinity (A-B transition). The rate constants and activation parameters of this transition were measured and are discussed. It is inferred that such a conformation transition may occur due to the binding of the first Co(Ⅱ) ion with the peptide segment of N-terminal residues 1-3, which results in a 'hinged movement' of the relatively hydrophobic 'valley' in the IA subdomain. This process leads to a slow conformational transition in the albumins, makes the other binding sites of Co(Ⅱ) exposed, and shows a positive cooperativity effect. The LMCT (ligand-to-metal charge transition) bands of the Co(Ⅱ)-HSA and Co(Ⅱ)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism. This phenomenon is rarely reported.
Co(, Ⅱ), -serum albumin, Hysteretic effect, Conformation transition, Hypochromic effect
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梁宏, Zhen-Feng Chen a, c, , Hong Liang a, *, Huai-Ming Hu b, Yan Li b, Ren-Gen Xiong c, Xiao-Zeng You c
Inorganic Chemistry Communications 6 (2003) 241-243,-0001,():
-1年11月30日
The hydrothermal reaction of norfloxacin (H-Norf) with NH4VO3 yields an unprecedented neutral nanosized molecular square grid containing a direct coordinate bond between quinololine drug and V(Ⅱ), V(Norf)2·2H2O 1, which is characterized by single Xray determination and IR spectrum as well as TGA.
Crystal structure, Norfloxacin, Vanadium(, Ⅱ), complex, Hydrothermal synthesis
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【期刊论文】Hysteresis effects of the interaction between serum albumins and silver nanoparticles
梁宏, SHEN Xingcan, , YUAN Qi, LIANG Hong, YAN Haigang & HE Xiwen
SCIENCE IN CHINA (Series B) August 2003 Vol. 46 No.4 387~398,-0001,():
-1年11月30日
The mechanisms and effects about the interaction between serum albumins and silver nanoparticles have been intensively studied by means of transmission electron microscopy (TEM), circular dichroism (CD) and ultraviolet-visible (UV-Vis) spectroscopy. The adsorption of serum albumins on the surface of silver nanoparticles is observed by TEM. The studies with the surface plasmon bands indicate that the electrostatic and hydrophilic interactions are the major forces between serum albumins and silver nanoparticles; the number of adsorbed monolayer serum albumin molecules to a silver nanoparticle with the size of 60nm is about 6.7
serum albumins,, silver nanoparticles,, hysteresis effect,, conformational transition,, surface plasmon band.,
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【期刊论文】Crystal structure of zinc(Ⅱ) complex with thiosemicarbazone of acetone
梁宏, Hong Liang a*, Bin Liu a, Rui-Xiang Hu a and Kai-Bei Yu b
J. Indian Chem. Soc., Vol. 77, October 2000, pp. 486-487,-0001,():
-1年11月30日
Synthesis and crystal structure determination of the title complex are presented. It shows that the zinc atom located in the distorted tetrahedral coordination, is composed of two nitrogen atoms and two sulfur atoms from the two ligand.
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