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王韵, Zi-Wei Chen, Kui Yang, Yun Wang and Ji-Sheng Han
Lippincott Williams & Wilkins Vol 12 No 4 26 March 2001,-0001,():
-1年11月30日
Recent studies have demonstrated the analgesic synergy between
DAMGO, DPDPE, Microphysiometer, SH-SY5Y cells, Synergy,
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【期刊论文】Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat
王韵, Ming Fang, Yun Wang, Hong-Xiang Liu, Xue-Song Liu and Ji-Sheng Han CA
Lippincott Williams & Wilkins Vol 11 No 4 20 March 2000,-0001,():
-1年11月30日
This work was supported by the National Natural Science Foundation of China (Grant Nos. 39770848, 39830160), and a grant from NIH (DA 03983), USA. It is now well established that nerve growth factor (NGF) plays a key role in inammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status. NeuroReport 11:737-741
Arthritis, Chronic pain, GDNF, Neurotrophin, Rat, Spinal cord
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王韵, M. FANG, Y. WANG, Q. H. HE, Y. X. SUN, L. B. DENG, X. M. WANG AND J. S. HAN *
Neuroscience 117(2003)503-512,-0001,():
-1年11月30日
Neurotrophic factors, such as nerve growth factor and brain-derived neurotrophic factor, are members of the structurally related neurotrophin family that play important roles in pain modulation. Although there are also indications for the involvement of glial cell line-derived neurotrophic factor (GDNF), it is unclear whether and how GDNF is involved in inflammatory pain. In the present study, we studied the expression pattern of GDNF in dorsal root ganglia (DRG) and spinal cord, using confocal microscopy. We demonstrate that GDNF is well associated with nonpeptidergic pain pathway and that GDNF could possibly be anterogradely transported from DRG neurons to superficial spinal cord dorsal horn. We also studied the dynamic changes of GDNF expression in rats during chronic inflammation using injection of complete Freund's adjuvant as a model of chronic pain. We found that GDNF was down-regulated in both dorsal root ganglia and spinal cords 2 weeks after arthritis induction. To assess the impact of this down-regulation on pain transmission, we used a function-blocking antibody against GDNF delivered intrathecally in the same chronic-pain animal models. Injection of this antibody to GDNF produced no immediate effect, but decreased the delayed, bilateral hyperalgesia induced from a unilateral injection of complete Freund's adjuvant. The effect of this antibody coincided with the downregulation of GDNF immunoreactivity in response to inflammation, suggesting that GDNF supports biochemical changes that contribute to hyperalgesia.
GDNF,, pain pathway,, nociception,, arthritis,, IB4
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【期刊论文】High-Affinity Partial Agonists of the Vanilloid Receptor
王韵, YUN WANG, ATTILA TOTH, RICHARD TRAN, TAMAS SZABO, JACQUELINE D. WELTER, PETER M. BLUMBERG, JIYOUN LEE, SANG-UK KANG, JU-OK LIM, and JEEWOO LEE
MOLECULAR PHARMACOLOGY Vol. 64, No.2 ,-0001,():
-1年11月30日
The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, and heat. Because VR1 represents an attractive therapeutic target for conditions ranging from long-term pain to bladder hyperreflexia, we and other groups have sought to develop novel ligands with enhanced potencies and novel pharmacological properties. Here, we characterize two compounds, N-[2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl]-N -[4-(methylsulfonylamino)benzyl]thiourea (JYL827) and N-(4-tert-butylbenzyl)-N+-[3-methoxy-4-(methylsulfonylamino)benzyl]thiourea (JYL1511), that function as partial agonists for rat VR1 heterologously expressed in Chinese hamster ovary cells. Both compounds showed substantially enhanced potency, inhibiting [3H] resiniferatoxin binding with Ki values of 29.3
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王韵, Yun Wang, Cheng Huang, Yu Cao, Ji-Sheng Han *
Life Sciences 67(2000)261-267,-0001,():
-1年11月30日
The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute in
Ketamine, Monoarthritis, Pain
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